Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Division of Endocrinology, Cincinnati Children's Hospital Medical Center, 3333 Burnet Ave. MLC 7012, Cincinnati, OH, 45229, USA.
Curr Diab Rep. 2019 Jan 21;19(1):3. doi: 10.1007/s11892-019-1120-y.
This review describes the literature evaluating the potential adverse effects of youth-onset type 2 diabetes on the developing brain. A summary of recently published articles and the current state of knowledge are covered succinctly in this manuscript.
Current literature suggests both cognitive and brain structural differences are found in youth with type 2 diabetes. Studies have shown poorer scores in a number of neurocognitive domains, particularly in areas of executive functioning and memory. Additionally, imaging studies have found differences in brain gray matter volume, white matter volume, and microstructural integrity. These findings are largely consistent with the adult literature. Youth with type 2 diabetes demonstrate lower cognitive scores and structural brain differences. Although causality has not yet been established, these findings are important because these individuals are still undergoing neurodevelopmental maturation.
本文综述了评估青少年 2 型糖尿病对发育中大脑潜在不良影响的文献。本文简明扼要地总结了最近发表的文章和当前的知识状况。
目前的文献表明，2 型糖尿病青少年的认知和大脑结构存在差异。研究表明，他们在许多神经认知领域的得分较差，特别是在执行功能和记忆方面。此外，影像学研究发现大脑灰质体积、白质体积和微观结构完整性存在差异。这些发现与成人文献基本一致。2 型糖尿病青少年的认知评分和大脑结构差异较低。尽管尚未确定因果关系，但这些发现很重要，因为这些人仍在经历神经发育成熟。
