Laboratorio Ciencias Biomédicas/Área Histología y Psicobiologia, Departamento de Ciencias de la Tierra y de la Vida. Centro Universitario de Los Lagos, Universidad de Guadalajara. Lagos de Moreno, Jalisco, México. Av. Enrique Díaz de León 1144. Col. Paseos de la Montaña, Lagos de Moreno, Jalisco, Mexico.
Laboratorio Ciencias Biomédicas/Área Histología y Psicobiologia, Departamento de Ciencias de la Tierra y de la Vida. Centro Universitario de Los Lagos, Universidad de Guadalajara. Lagos de Moreno, Jalisco, México. Av. Enrique Díaz de León 1144. Col. Paseos de la Montaña, Lagos de Moreno, Jalisco, Mexico.
Phytomedicine. 2019 Mar 1;55:9-13. doi: 10.1016/j.phymed.2018.07.007. Epub 2018 Jul 18.
In Mexico, an infusion made from muicle (Justicia spicigera, Mexican honeysuckle) is used to treat menstrual problems and soothe people's "nerves" (i.e., anxiety and/or depression). However, no studies have yet substantiated these affects. Anxiety currently ranks as the seventh most common cause of disability worldwide, a fact that has intensified the search for new treatments with fewer adverse effects and better therapeutic efficacy.
The anxiolytic-like effect of the aqueous extract of muicle leaves (AEML) was analyzed, and the influence of the estrous cycle on its pharmacological effect in rats was explored.
Female Wistar rats were subjected to the elevated plus maze test to evaluate the anxiolytic effect, followed by an assessment of locomotor activity using the open field test. Diazepam was the reference drug used. Preliminary phytochemical tests were performed.
The dose of 12 mg/kg of AEML increased the time to first entry, and the frequency of entries into, the open arms in the proestrus-estrus (P-E) and metestrus-diestrus phases (M-D), while also reducing the anxiety index in the P-E phases. These effects are similar to those observed with diazepam on the elevated plus maze test. None of the treatments showed effects on locomotor activity. The presence of flavonoids, sterols and terpenes in the AEML was confirmed.
The anxiolytic-like effect of the dose of 12 mg/kg of AEML in the P-E phases could be due to the presence of the metabolites identified; i.e., flavonoids, sterols and/or terpenes.
在墨西哥，有一种由 muicle（Justicia spicigera，墨西哥忍冬）制成的输液被用于治疗月经问题和舒缓人们的“神经”（即焦虑和/或抑郁）。然而，目前还没有研究证实这些作用。焦虑症目前是全球第七大常见的致残原因，这一事实加剧了人们对新的治疗方法的寻找，这些方法的副作用更少，治疗效果更好。
分析 muicle 叶水提物（AEML）的抗焦虑样作用，并探讨动情周期对其在大鼠中的药理作用的影响。
雌性 Wistar 大鼠进行高架十字迷宫测试以评估抗焦虑作用，然后使用旷场测试评估其运动活性。地西泮为参考药物。进行了初步的植物化学测试。
12mg/kg 的 AEML 剂量增加了动情前期-发情期（P-E）和动情后期-间情期（M-D）进入开放臂的首次进入时间和进入频率，同时降低了 P-E 期的焦虑指数。这些作用与地西泮在高架十字迷宫测试中的作用相似。所有治疗方法均未显示对运动活性的影响。AEML 中存在黄酮类、甾醇和萜类化合物得到了证实。
12mg/kg 的 AEML 在 P-E 期的抗焦虑样作用可能归因于所鉴定的代谢物的存在；即黄酮类、甾醇和/或萜类化合物。
