Department of Pesticide Regulation, California Environmental Protection Agency, Sacramento, 1001 I Street, Sacramento, CA 95812, United States.
Department of Pesticide Regulation, California Environmental Protection Agency, Sacramento, 1001 I Street, Sacramento, CA 95812, United States.
Reprod Toxicol. 2019 Apr;85:12-18. doi: 10.1016/j.reprotox.2019.01.004. Epub 2019 Jan 19.
There is growing concern that increased use of medical and recreational cannabis may result in increased exposure to contaminants on the cannabis, such as pesticides. Several states are moving towards implementing robust regulation of the sales, cultivation, and manufacture of cannabis products. However, there are challenges with creating health-protective regulations in an industry that, to date, has been largely unregulated. The focus of this publication is a theoretical examination of what may happen when women are exposed pre-conceptually or during pregnancy to cannabis contaminated with pesticides. We propose an adverse outcome pathway of concomitant prenatal exposure to cannabinoids and the organophosphate pesticide chlorpyrifos by curating what we consider to be the key events at the molecular, cellular, and tissue levels that result in developmental neurotoxicity. The implications of this adverse outcome pathway underscore the need to elucidate the potential developmental neurotoxicity that may result from prenatal exposure to pesticide-contaminated cannabis.
人们越来越担心，医疗和娱乐用大麻的使用增加可能会导致大麻上的污染物暴露增加，例如农药。一些州正在朝着实施对大麻产品的销售、种植和制造进行严格监管的方向发展。然而，在一个迄今为止基本上不受监管的行业中制定保护健康的法规存在挑战。本出版物的重点是理论上研究女性在怀孕前或怀孕期间接触到被农药污染的大麻时可能会发生什么。我们通过整理我们认为在导致发育神经毒性的分子、细胞和组织水平上的关键事件，提出了在产前同时暴露于大麻素和有机磷农药毒死蜱的不良后果途径。这一不良后果途径的意义强调了阐明产前接触受农药污染的大麻可能导致的潜在发育神经毒性的必要性。
