可吸收锌合金在人工尿液中的体外降解

Champagne Sébastien, Mostaed Ehsan, Safizadeh Fariba, Ghali Edward, Vedani Maurizio, Hermawan Hendra

Department of Mining, Metallurgical and Materials Engineering, Laval University, 1065 avenue de la Médecine, Québec, QC G1V 0A6, Canada.

Research Center of CHU de Québec, 10 rue de l'Espinay, Québec, QC G1L 3L5, Canada.

Materials (Basel). 2019 Jan 18;12(2):295. doi: 10.3390/ma12020295.

Absorbable metals have potential for making in-demand rigid temporary stents for the treatment of urinary tract obstruction, where polymers have reached their limits. In this work, in vitro degradation behavior of absorbable zinc alloys in artificial urine was studied using electrochemical methods and advanced surface characterization techniques with a comparison to a magnesium alloy. The results showed that pure zinc and its alloys (Zn⁻0.5Mg, Zn⁻1Mg, Zn⁻0.5Al) exhibited slower corrosion than pure magnesium and an Mg⁻2Zn⁻1Mn alloy. The corrosion layer was composed mostly of hydroxide, carbonate, and phosphate, without calcium content for the zinc group. Among all tested metals, the Zn⁻0.5Al alloy exhibited a uniform corrosion layer with low affinity with the ions in artificial urine.

在聚合物已达到其极限的情况下，可吸收金属有潜力制造用于治疗尿路梗阻的急需的刚性临时支架。在这项工作中，使用电化学方法和先进的表面表征技术，研究了可吸收锌合金在人工尿液中的体外降解行为，并与镁合金进行了比较。结果表明，纯锌及其合金（Zn⁻0.5Mg、Zn⁻1Mg、Zn⁻0.5Al）的腐蚀速度比纯镁和Mg⁻2Zn⁻1Mn合金慢。腐蚀层主要由氢氧化物、碳酸盐和磷酸盐组成，锌组不含钙。在所有测试金属中，Zn⁻0.5Al合金表现出均匀的腐蚀层，与人工尿液中的离子亲和力低。