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印度能否引领被忽视疾病创新之路？

Can India lead the way in neglected diseases innovation?

机构信息

Central Board of Direct Taxes, Department of Revenue, Ministry of Finance, New Delhi, India.

Open Source Drug Discovery, India.

出版信息

BMJ. 2019 Jan 22;364:k5396. doi: 10.1136/bmj.k5396.

DOI:10.1136/bmj.k5396
PMID:30670384
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6340354/
Abstract

call for a comprehensive policy for neglected diseases research in India to foster innovation in drugs, diagnostics, and vaccines, critical for evolving needs of elimination programmes

摘要

呼吁制定一项综合性的印度被忽视疾病研究政策，以促进药物、诊断和疫苗方面的创新，这对于不断变化的消除规划需求至关重要

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本文引用的文献

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Orphans in the Market: The History of Orphan Drug Policy.市场中的孤儿药：孤儿药政策的历史
Soc Hist Med. 2019 Aug;32(3):609-630. doi: 10.1093/shm/hkx098. Epub 2017 Nov 27.
2
Why miltefosine-a life-saving drug for leishmaniasis-is unavailable to people who need it the most.为什么米替福新这种治疗利什曼病的救命药物，却无法提供给最需要它的人。
BMJ Glob Health. 2018 May 3;3(3):e000709. doi: 10.1136/bmjgh-2018-000709. eCollection 2018.
3
The bacterium Wolbachia exploits host innate immunity to establish a symbiotic relationship with the dengue vector mosquito Aedes aegypti.细菌沃尔巴克氏体利用宿主固有免疫与登革热传播媒介埃及伊蚊建立共生关系。
ISME J. 2018 Jan;12(1):277-288. doi: 10.1038/ismej.2017.174. Epub 2017 Nov 3.
4
Why is every country not primed to use oral rehydration therapy to treat cases of diarrhoea?为什么不是每个国家都准备好使用口服补液疗法来治疗腹泻病例呢？
WHO South East Asia J Public Health. 2012 Jan-Mar;1(1):113-115. doi: 10.4103/2224-3151.206907.
5
What Is the Purpose of the Orphan Drug Act?《孤儿药法案》的目的是什么？
PLoS Med. 2017 Jan 3;14(1):e1002191. doi: 10.1371/journal.pmed.1002191. eCollection 2017 Jan.
6
Gene deleted live attenuated Leishmania vaccine candidates against visceral leishmaniasis elicit pro-inflammatory cytokines response in human PBMCs.基因缺失的活减毒利什曼原虫疫苗候选物对内脏利什曼病在人 PBMCs 中引发促炎细胞因子反应。
Sci Rep. 2016 Sep 14;6:33059. doi: 10.1038/srep33059.
7
Challenges in new vaccine introduction in a national program in India.在印度全国疫苗接种计划中引入新疫苗所面临的挑战。
Indian J Public Health. 2016 Jul-Sep;60(3):171-5. doi: 10.4103/0019-557X.188995.
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The oral cholera vaccine Shanchol™ when stored at elevated temperatures maintains the safety and immunogenicity profile in Bangladeshi participants.口服霍乱疫苗Shanchol™在高温储存时，在孟加拉国参与者中保持了安全性和免疫原性。
Vaccine. 2016 Mar 18;34(13):1551-1558. doi: 10.1016/j.vaccine.2016.02.020. Epub 2016 Feb 16.
9
Single-dose indigenous liposomal amphotericin B in the treatment of Indian visceral leishmaniasis: a phase 2 study.单剂量国产脂质体两性霉素B治疗印度内脏利什曼病：一项2期研究。
Am J Trop Med Hyg. 2015 Mar;92(3):513-7. doi: 10.4269/ajtmh.14-0259. Epub 2014 Dec 15.
10
Safety and immunogenicity of a live oral recombinant cholera vaccine VA1.4: a randomized, placebo controlled trial in healthy adults in a cholera endemic area in Kolkata, India.口服重组霍乱活疫苗VA1.4的安全性和免疫原性：在印度加尔各答霍乱流行地区健康成年人中进行的一项随机、安慰剂对照试验
PLoS One. 2014 Jul 1;9(7):e99381. doi: 10.1371/journal.pone.0099381. eCollection 2014.