Fatima Iram, Kanwal Sobia, Mahmood Tariq
Department of Plant Sciences, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, Pakistan.
Department of Zoology, University of Gujrat Sub-campus Rawalpindi, Rawalpindi, Pakistan.
Dose Response. 2019 Jan 8;17(1):1559325818813227. doi: 10.1177/1559325818813227. eCollection 2019 Jan-Mar.
The role of viral infection in developing cancer was determined in the start of 20th century. Until now, 8 different virus-associated cancers have been discovered and most of them progressed in immunosuppressed individuals. The aim of the present study is to look into the benefits of natural products in treating virally infected cancers. The study focuses on bioactive compounds derived from natural sources. Numerous pharmaceutical agents have been identified from plants (vincristine, vinblastine, stilbenes, combretastatin, and silymarin), marine organisms (bryostatins, cephalostatin, ecteinascidins, didemnin, and dolastatin), insects (cantharidin, mastoparan, parectadial, and cecropins), and microorganisms (vancomycin, rhizoxin, ansamitocins, mitomycin, and rapamycin). Beside these, various compounds have been observed from fruits and vegetables which can be utilized in anticancer therapy. These include curcumin in turmeric, resveratrol in red grapes, S-allyl cysteine in allium, allicin in garlic, catechins in green tea, and β-carotene in carrots. The present study addresses various types of virally infected cancers, their mechanism of action, and the role of different cell surface molecules elicited during viral binding and entry into the target cell along with the anticancer drugs derived from natural products by targeting screening of bioactive compounds from natural sources.
病毒感染在癌症发生中的作用于20世纪初得以确定。截至目前，已发现8种不同的病毒相关癌症，其中大多数在免疫抑制个体中进展。本研究的目的是探究天然产物在治疗病毒感染癌症方面的益处。该研究聚焦于源自天然来源的生物活性化合物。已从植物（长春新碱、长春碱、芪类、combretastatin和水飞蓟宾）、海洋生物（苔藓抑素、头霉素、海鞘素、didemnin和多拉司他汀）、昆虫（斑蝥素、mastoparan、parectadial和杀菌肽）以及微生物（万古霉素、根霉素、安丝菌素、丝裂霉素和雷帕霉素）中鉴定出众多药物制剂。除此之外,人们还从水果和蔬菜中观察到了多种可用于抗癌治疗的化合物。这些包括姜黄中的姜黄素、红葡萄中的白藜芦醇、葱属中的S -烯丙基半胱氨酸、大蒜中的蒜素、绿茶中的儿茶素以及胡萝卜中的β -胡萝卜素。本研究通过对天然来源生物活性化合物进行靶向筛选，探讨了各种类型的病毒感染癌症、它们的作用机制，以及病毒结合并进入靶细胞过程中引发的不同细胞表面分子的作用，同时还涉及了源自天然产物的抗癌药物。
