Xu Dongwei, Xu Min, Jeong Seogsong, Qian Yihan, Wu Hailong, Xia Qiang, Kong Xiaoni
Department of Liver Surgery, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
School of Pharmacy, Fudan University, Shanghai, China.
Front Pharmacol. 2019 Jan 8;9:1428. doi: 10.3389/fphar.2018.01428. eCollection 2018.
Oxidative stress and inflammation are the most important pathogenic events in the development and progression of liver diseases. Nuclear erythroid 2-related factor 2 (Nrf2) is the master regulator of the cellular protection induction of anti-inflammatory, antioxidant, and cyto-protective genes expression. Multiple studies have shown that activation or suppression of this transcriptional factor significantly affect progression of liver diseases. Comprehensive understanding the roles of Nrf2 activation/expression and the outcomes of its activators/inhibitors are indispensable for defining the mechanisms and therapeutic strategies against liver diseases. In this current review, we discussed recent advances in the function and principal mechanisms by regulating Nrf2 in liver diseases, including acute liver failure, hepatic ischemia-reperfusion injury (IRI), alcoholic liver disease (ALD), viral hepatitis, non-alcoholic fatty liver disease (NAFLD), non-alcoholic steatohepatitis (NASH), and hepatocellular carcinoma (HCC).
氧化应激和炎症是肝脏疾病发生和发展过程中最重要的致病事件。核红细胞2相关因子2（Nrf2）是诱导抗炎、抗氧化和细胞保护基因表达的细胞保护作用的主要调节因子。多项研究表明，该转录因子的激活或抑制会显著影响肝脏疾病的进展。全面了解Nrf2激活/表达的作用及其激活剂/抑制剂的效果，对于明确肝病的发病机制和治疗策略必不可少。在本综述中，我们讨论了通过调节Nrf2在肝病（包括急性肝衰竭、肝缺血再灌注损伤（IRI）、酒精性肝病（ALD）、病毒性肝炎、非酒精性脂肪性肝病（NAFLD）、非酒精性脂肪性肝炎（NASH）和肝细胞癌（HCC））中的功能及主要机制方面的最新进展。
