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睾丸旁肉瘤:病例系列及文献综述

Paratesticular sarcomas: a case series and literature review.

作者信息

Keenan Robert Anthony, Nic An Riogh Aisling U, Stroiescu Andrea, Fuentes Adrian, Heneghan Joan, Cullen Ivor M, Daly Padraig J

机构信息

Department of Urology, University Hospital Waterford, Waterford, X91 ER83, Ireland.

Department of Urology, University Hospital Waterford, Waterford, Ireland.

出版信息

Ther Adv Urol. 2019 Jan 8;11:1756287218818029. doi: 10.1177/1756287218818029. eCollection 2019 Jan-Dec.

Abstract

Paratesticular soft tissue tumours are remarkably rare entities, with malignant subtypes accounting for approximately 30%. Due to the paucity of cases, a consensus on the best treatment has not yet been reached, presenting a diagnostic and therapeutic challenge for clinicians. Although rare, three such cases presented to the care of our institution serving a population of approximately 400,000 in the space of 13 months. These were three gentlemen, aged 54, 82 and 86 years old, presenting with left sided testicular swellings. Ultrasound in each case confirmed an extratesticular mass. Only the second gentleman complained of associated pain, however he had experienced scrotal trauma in the preceding weeks. Only one patient had suspicions of metastatic disease, with a 9 mm pulmonary nodule on computed tomography. All patients underwent a radical inguinal orchidectomy with high ligation of the spermatic cord, in keeping with best accepted guidelines. Histology confirmed a well-differentiated liposarcoma, a dedifferentiated liposarcoma and a leiomyosarcoma respectively, all high grade. One gentleman returned to theatre for re-excision of margins. Our case series emphasises the need for full multidisciplinary team specialist sarcoma input, as well as radical resection with judicious margins in order to reduce the risk of local recurrence, in the treatment of these rare tumours.

摘要

睾丸旁软组织肿瘤是极为罕见的疾病,恶性亚型约占30%。由于病例稀少,尚未就最佳治疗方案达成共识,这给临床医生带来了诊断和治疗方面的挑战。尽管罕见,但在13个月内,有3例这样的病例在我们服务于约40万人口的机构接受治疗。这3位男性患者年龄分别为54岁、82岁和86岁,均表现为左侧睾丸肿胀。每例患者的超声检查均证实存在睾丸外肿块。只有第二位患者主诉伴有疼痛,不过他在之前几周有阴囊外伤史。只有1例患者怀疑有转移性疾病,计算机断层扫描显示有一个9毫米的肺结节。所有患者均按照公认的最佳指南接受了根治性腹股沟睾丸切除术及精索高位结扎术。组织学检查分别证实为高分化脂肪肉瘤、去分化脂肪肉瘤和平滑肌肉瘤,均为高级别。有一位男性患者返回手术室进行切缘再次切除。我们的病例系列强调,在治疗这些罕见肿瘤时,需要多学科团队的肉瘤专家全面参与,以及进行有合理切缘的根治性切除,以降低局部复发的风险。

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