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在参与 2011-2013 年澳大利亚健康调查的具有全国代表性的成年人样本中,维生素 D 缺乏症的流行情况及其预测因素。

Prevalence and predictors of vitamin D deficiency in a nationally representative sample of adults participating in the 2011-2013 Australian Health Survey.

机构信息

1School of Public Health,Curtin University,Kent Street,Bentley,WA 6102,Australia.

3National Centre for Epidemiology and Population Health,Research School of Population Health,Australian National University,Acton,ACT 2600,Australia.

出版信息

Br J Nutr. 2019 Apr;121(8):894-904. doi: 10.1017/S0007114519000151. Epub 2019 Jan 24.

DOI:10.1017/S0007114519000151
PMID:30674358
Abstract

Vitamin D deficiency is recognised as a public health problem globally, and a high prevalence of deficiency has previously been reported in Australia. This study details the prevalence of vitamin D deficiency in a nationally representative sample of Australian adults aged ≥25 years, using an internationally standardised method to measure serum 25-hydroxyvitamin D (25(OH)D) concentrations and identifies demographic and lifestyle factors associated with vitamin D deficiency. We used data from the 2011-2013 Australian Health Survey (n 5034 with complete information on potential predictors and serum 25(OH)D concentrations). Serum 25(OH)D concentrations were measured by a liquid chromatography-tandem MS that is certified to the reference measurement procedures developed by the National Institute of Standards and Technology, Ghent University and the US Centers for Disease Control and Prevention. Vitamin D deficiency and insufficiency were defined as serum 25(OH)D concentrations <50 nmol/l and 50 to <75 nmol/l, respectively. Overall, 20 % of participants (19 % men; 21 % women) were classified as vitamin D deficient, with a further 43 % classified as insufficient (45 % men; 42 % women). Independent predictors of vitamin D deficiency included being born in a country other than Australia or the main English-speaking countries, residing in southern (higher latitude) states of Australia, being assessed during winter or spring, being obese, smoking (women only), having low physical activity levels and not taking vitamin D or Ca supplements. Given our increasingly indoor lifestyles, there is a need to develop and promote strategies to maintain adequate vitamin D status through safe sun exposure and dietary approaches.

摘要

维生素 D 缺乏症在全球范围内被认为是一个公共卫生问题,澳大利亚以前也有过维生素 D 缺乏症的高患病率报道。本研究采用国际标准化方法测量血清 25-羟维生素 D(25(OH)D)浓度,详细描述了澳大利亚≥25 岁成年人中维生素 D 缺乏的流行情况,并确定了与维生素 D 缺乏相关的人口统计学和生活方式因素。我们使用了来自 2011-2013 年澳大利亚健康调查的数据(n=5034,有完整的潜在预测因素和血清 25(OH)D 浓度信息)。血清 25(OH)D 浓度采用经认证符合国家标准与技术研究所、根特大学和美国疾病控制与预防中心制定的参考测量程序的液相色谱-串联质谱法测量。维生素 D 缺乏和不足定义为血清 25(OH)D 浓度 <50 nmol/l 和 50 至 <75 nmol/l。总体而言,20%的参与者(19%的男性;21%的女性)被归类为维生素 D 缺乏,另有 43%被归类为不足(45%的男性;42%的女性)。维生素 D 缺乏的独立预测因素包括出生在澳大利亚或主要英语国家以外的国家、居住在澳大利亚南部(高纬度)州、在冬季或春季接受评估、肥胖、吸烟(仅限女性)、体力活动水平低以及不服用维生素 D 或 Ca 补充剂。考虑到我们日益增加的室内生活方式,需要制定和推广通过安全的阳光暴露和饮食方法来维持足够维生素 D 状态的策略。

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