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哺乳动物细胞上的涂层：使细胞与其环境相互作用。

Coatings on mammalian cells: interfacing cells with their environment.

作者信息

Davis Kara A, Wu Pei-Jung, Cahall Calvin F, Li Cong, Gottipati Anuhya, Berron Brad J

机构信息

Chemical and Materials Engineering, University of Kentucky, 177 FPAT, Lexington, KY 40506-0046 USA.

出版信息

J Biol Eng. 2019 Jan 17;13:5. doi: 10.1186/s13036-018-0131-6. eCollection 2019.

DOI:10.1186/s13036-018-0131-6
PMID:30675178
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6337841/
Abstract

The research community is intent on harnessing increasingly complex biological building blocks. At present, cells represent a highly functional component for integration into higher order systems. In this review, we discuss the current application space for cellular coating technologies and emphasize the relationship between the target application and coating design. We also discuss how the cell and the coating interact in common analytical techniques, and where caution must be exercised in the interpretation of results. Finally, we look ahead at emerging application areas that are ideal for innovation in cellular coatings. In all, cellular coatings leverage the machinery unique to specific cell types, and the opportunities derived from these hybrid assemblies have yet to be fully realized.

摘要

科研界致力于利用日益复杂的生物构建模块。目前，细胞是集成到高阶系统中的一种高度功能性组件。在本综述中，我们讨论了细胞包被技术的当前应用领域，并强调了目标应用与包被设计之间的关系。我们还讨论了在常见分析技术中细胞与包被如何相互作用，以及在结果解释中必须谨慎的地方。最后，我们展望了细胞包被创新的理想新兴应用领域。总体而言，细胞包被利用特定细胞类型独有的机制，而这些混合组装带来的机遇尚未得到充分实现。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2503/6337841/991a67f045e7/13036_2018_131_Fig17_HTML.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2503/6337841/3eae123c458f/13036_2018_131_Fig16_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2503/6337841/991a67f045e7/13036_2018_131_Fig17_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2503/6337841/91bbe5c32247/13036_2018_131_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2503/6337841/c37fffad4393/13036_2018_131_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2503/6337841/dd9b00c5feb2/13036_2018_131_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2503/6337841/37fe0d29c4f3/13036_2018_131_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2503/6337841/998ecfbebfda/13036_2018_131_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2503/6337841/81f7c449c17f/13036_2018_131_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2503/6337841/5324e2f6ef73/13036_2018_131_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2503/6337841/68f77c630701/13036_2018_131_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2503/6337841/bc14d494683f/13036_2018_131_Fig9_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2503/6337841/7a67746fd4d2/13036_2018_131_Fig10_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2503/6337841/aa7b393002ce/13036_2018_131_Fig11_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2503/6337841/261a5dc06141/13036_2018_131_Fig12_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2503/6337841/26e3cca20442/13036_2018_131_Fig13_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2503/6337841/b54c2eff3f2a/13036_2018_131_Fig14_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2503/6337841/67ac1470b307/13036_2018_131_Fig15_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2503/6337841/3eae123c458f/13036_2018_131_Fig16_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2503/6337841/991a67f045e7/13036_2018_131_Fig17_HTML.jpg

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