Yuan Guangyi, Wu Haoming, Du Yu, He Fanglin
Department of Oral and Maxillofacial Surgery, Shunde Hospital of Guangzhou Medical University, Foshan, Guangdong 528315, P.R. China.
Department of Oral and Maxillofacial Surgery, Foshan Chancheng District Xiangyang Hospital, Foshan, Guangdong 52800, P.R. China.
Oncol Lett. 2019 Feb;17(2):2063-2068. doi: 10.3892/ol.2018.9820. Epub 2018 Dec 11.
Oral squamous cell carcinoma (OSCC) is the predominant histological type of oral cancer, and poses an important threat to human health. MicroRNA (miRNA) serves important functions in the pathogenesis of OSCC, and in that of other types of cancer. For example, miR-545 exhibits inhibitory functions in pancreatic ductal adenocarcinoma, lung cancer and hepatocellular carcinoma. In the present study, the function of miR-545 was assessed in OSCC. Obtained results indicated decreased levels of miR-545 in OSCC tissues when comparing with the adjacent normal tissues. Overexpression of miR-545 inhibited HSC4 cells proliferation and migration, and vice versa. Furthermore, miR-545 was identified to target the 3'-UTR of retinoic acid-inducible gene-I (RIG-I), and there was a negative association between RIG-I mRNA expression and miR-545 expression in the 20 OSCC tissues. In conclusion, the present data demonstrate the tumor suppressive role of miR-545 in OSCC.
口腔鳞状细胞癌（OSCC）是口腔癌的主要组织学类型，对人类健康构成重大威胁。微小RNA（miRNA）在OSCC及其他类型癌症的发病机制中发挥重要作用。例如，miR-545在胰腺导管腺癌、肺癌和肝细胞癌中具有抑制功能。在本研究中，对miR-545在OSCC中的功能进行了评估。所得结果表明，与相邻正常组织相比，OSCC组织中miR-545水平降低。miR-545的过表达抑制了HSC4细胞的增殖和迁移，反之亦然。此外，miR-545被确定为视黄酸诱导基因-I（RIG-I）3'-UTR的靶点，并且在20例OSCC组织中，RIG-I mRNA表达与miR-545表达之间呈负相关。总之，本研究数据证明了miR-545在OSCC中的肿瘤抑制作用。
