Clinical and Practice Research Group, School of Pharmacy, Queen's University Belfast, Belfast, BT9 7BL, UK.
Faculty of Pharmaceutical Sciences, Hashemite University, Jordan.
Br J Clin Pharmacol. 2019 Mar;85(3):616-625. doi: 10.1111/bcp.13839. Epub 2019 Jan 24.
To implement pharmacist-led, postdischarge telephone follow-up (TFU) intervention and to evaluate its impact on rehospitalization parameters in polypharmacy patients, via comparison with a well-matched control group.
Pragmatic, prospective, quasi-experimental study. Intervention patients were matched by propensity score techniques with a control group. Guided by results from a pilot study, clinical pharmacists implemented TFU intervention, added to routine integrated medicines management service.
Using an intention to treat approach, reductions in 30- and 90-day readmission rates for intervention patients compared with controls were 9.9% [odds ratio = 0.57; 95% confidence interval (CI): 0.36-0.90; P < 0.001] and 15.2% (odds ratio = 0.53; 95% CI: 0.36-0.79; P = 0.021) respectively. Marginal mean time to readmission was 70.9 days (95% CI: 66.9-74.9) for intervention group compared with 60.1 days (95% CI: 55.4-64.7) for controls. Mean length of hospital stay compared with control was (8.3 days vs. 6.7 days; P < 0.001). Benefit: cost ratio for 30-day readmissions was 29.62, and 23.58 for 90-day interval. Per protocol analyses gave more marked improvements. In intervention patients, mean concern scale score, using Beliefs about Medicine Questionnaire, was reduced 3.2 (95% CI: -4.22 to -2.27; P < 0.001). Mean difference in Medication Adherence Report Scale was 1.4 (22.7 vs. 24.1; P < 0.001). Most patients (83.8%) reported having better control of their medicines after the intervention.
Pharmacist-led postdischarge structured TFU intervention can reduce 30- and 90-day readmission rates. Positive impacts were noted on time to readmission, length of hospital stay upon readmission, healthcare costs, patient beliefs about medicines, patient self-reported adherence and satisfaction.
通过与匹配良好的对照组进行比较,实施药剂师主导的出院后电话随访(TFU)干预,并评估其对多种药物治疗患者再入院参数的影响。
实用、前瞻性、准实验研究。通过倾向评分技术,将干预组患者与对照组患者进行匹配。在试点研究结果的指导下,临床药师实施 TFU 干预,作为常规综合药物管理服务的补充。
采用意向治疗方法,与对照组相比,干预组患者的 30 天和 90 天再入院率分别降低了 9.9%(优势比=0.57;95%置信区间[CI]:0.36-0.90;P<0.001)和 15.2%(优势比=0.53;95%CI:0.36-0.79;P=0.021)。干预组再入院的边缘平均时间为 70.9 天(95%CI:66.9-74.9),而对照组为 60.1 天(95%CI:55.4-64.7)。与对照组相比,住院时间的平均长度为(8.3 天与 6.7 天;P<0.001)。30 天再入院的效益-成本比为 29.62,90 天间隔为 23.58。方案分析给出了更显著的改善。在干预组中,使用信念量表(Beliefs about Medicine Questionnaire),平均关注量表评分降低了 3.2(95%CI:-4.22 至-2.27;P<0.001)。用药依从性报告量表的平均差值为 1.4(22.7 与 24.1;P<0.001)。大多数患者(83.8%)表示在干预后对他们的药物有更好的控制。
药剂师主导的出院后结构化 TFU 干预可以降低 30 天和 90 天的再入院率。在再入院时间、再入院时的住院时间、医疗保健成本、患者对药物的信念、患者自我报告的依从性和满意度方面都有积极影响。