Department of Medicinal Chemistry and Natural Medicine Chemistry, College of Pharmacy, HarBin Medical University, HarBin, People's Republic of China.
Department of Pharmacology, College of Pharmacy, HarBin Medical University, HarBin, People's Republic of China.
Nat Prod Res. 2020 May;34(9):1320-1325. doi: 10.1080/14786419.2018.1560288. Epub 2019 Jan 24.
As part of our continuing efforts to explore bioactive compounds from natural resources, a new iridoid glycoside, adoxosidic acid-6'-oleuroperic ester (), together with one known phenylethanoid glycoside () and two known flavonoid glycosides () were isolated from the fruit of . The structure of the new compound () was elucidated through 1D and 2D NMR spectroscopic data and HR-ESIMS. Interestingly, compound was a monoterpene ester of one iridoid glycoside. Compounds were identified as calceolarioside A (), kaempferol-3--rutinoside (), kampferol-3--robinobioside () on the basis of NMR spectroscopic data analyses and comparison with the data reported in the literature. The antiviral activity aganisist influenza A (H5N1) virus of compound was studied as well.
作为我们从自然资源中探索生物活性化合物的持续努力的一部分，从 的果实中分离得到了一个新的环烯醚萜糖苷，即梓醇-6'-油酸酯（），以及一个已知的苯乙醇苷（）和两个已知的黄酮苷（）。通过 1D 和 2D NMR 光谱数据和高分辨率电喷雾电离质谱（HR-ESIMS）确定了新化合物（）的结构。有趣的是，化合物 是一个环烯醚萜糖苷的单萜酯。根据 NMR 光谱数据分析和与文献报道的数据比较，化合物 被鉴定为獐牙菜苦苷 A（）、山柰酚-3-O-β-D-葡萄糖苷（）、山柰酚-3-O-新橙皮糖苷（）。还研究了化合物 的抗流感 A（H5N1）病毒的活性。
