Some terminal cancer patients wish to "go to a memorable place" or "return home." However, owing to various symptom burdens and physical dysfunction, these wishes are difficult for them to realize. The aim of the study is to verify whether simulated travel using virtual reality (VR travel) is efficacious in improving symptoms in terminal cancer patients. This is a prospective, multicenter, single-arm study. Twenty participants with terminal cancer were recruited from two palliative care wards; data were collected from November 2017 to April 2018. The VR software Google Earth VR was used. The primary endpoint was the change in the Edmonton Symptom Assessment System scores for each symptom before and after VR travel. The average age of the participants was 72.3 (standard deviation [SD] = 11.9) years. Significant improvements were observed for pain (2.35, SD = 2.25 vs. 1.15, SD = 2.03,  = 0.005), tiredness (2.90, SD = 2.71 vs. 1.35, SD = 1.90,  = 0.004), drowsiness (2.70, SD = 2.87 vs. 1.35, SD = 2.30,  = 0.012), shortness of breath (1.74, SD = 2.73 vs. 0.35, SD = 0.99,  = 0.022), depression (2.45, SD = 2.63 vs. 0.40, SD = 0.82,  = 0.001), anxiety (2.60, SD = 2.64 vs. 0.80, SD = 1.51,  < 0.001), and well-being (4.50, SD = 2.78 vs. 2.20, SD = 1.99,  < 0.001; pre- vs. post-VR travel score, respectively). No participants complained of serious side effects. This preliminary study suggests that VR travel can be efficacious and safe for terminal cancer patients for improving symptom burden.