From the Department of Neurology (C.B., C.L., C.E., F.F., S.R.), Medical University of Graz, Graz, Austria
University of British Columbia MRI Research Centre (C.B.), University of British Columbia, Vancouver, British Columbia, Canada.
AJNR Am J Neuroradiol. 2019 Mar;40(3):460-463. doi: 10.3174/ajnr.A5933. Epub 2019 Jan 24.
This study explored whether autoregulatory shifts in cerebral blood volume induce susceptibility changes large enough to be depicted by quantitative susceptibility mapping. Eight healthy subjects underwent fast quantitative susceptibility mapping at 3T while lying down to slowly decrease mean arterial pressure. A linear relationship between mean arterial pressure and susceptibility was observed in cortical and subcortical structures, likely representing vessels involved in autoregulation. The slope of this relationship is assumed to indicate the extent of cerebral vascular compliance.
本研究旨在探讨脑血容量的自动调节变化是否足以引起定量磁化率图可描绘的磁化率变化。8 名健康受试者在 3T 下进行快速定量磁化率成像，同时躺下以缓慢降低平均动脉压。在皮质和皮质下结构中观察到平均动脉压和磁化率之间存在线性关系，可能代表参与自动调节的血管。该关系的斜率被认为可以指示脑血管顺应性的程度。
