Sabău Mara, Boca Andreea Nicoleta, Ilies Roxana Flavia, Tătaru Alexandru
Department of Dermatology, Toxicology and Clinical Pharmacology, 'Iuliu Hatieganu' University of Medicine and Pharmacy, 400423 Cluj-Napoca, Romania.
Department of Pharmacology, Toxicology and Clinical Pharmacology, 'Iuliu Hatieganu' University of Medicine and Pharmacy, 400423 Cluj-Napoca, Romania.
Exp Ther Med. 2019 Feb;17(2):1073-1077. doi: 10.3892/etm.2018.6984. Epub 2018 Nov 16.
Atopic dermatitis (AD) is a chronic, highly pruritic skin disorder, with a broad spectrum of clinical manifestations, characterized by abnormal skin barrier function. High-frequency ultrasonography (HF-USG) is an instrument with potential use in a variety of skin conditions. Previous studies on HF-USG in AD reported that apparently non-lesional skin also presents barrier defects. We aimed to assess lesional and non-lesional skin of AD patients with the use of HF-USG, focusing on skin barrier function and inflammation. We included a group of AD patients and a control group. On both we performed analysis with the use of HF-USG. The thickness of the subepidermal low-echogenic band (SLEB) and the skin echogenity were recorded for active lesions, as well as non-lesional skin in all subjects included. For AD patients the clinical severity was measured using SCORing Atopic Dermatitis and correlated with Dermatology Life Quality Index (DLQI). The mean thickness of the hypoechoic band was wider in the lesional skin of AD. In the non-lesional skin of AD patients SLEB was identified to appear, but it was thinner. The skin echogenity of the control group was higher than that of AD patients. Our results indicate that skin ultrasonography is able to assess specific modifications of the AD skin. A hypoechoic band in the non-lesional skin of some AD patients may indicate subclinical eczematous lesions.
特应性皮炎（AD）是一种慢性、高度瘙痒性皮肤病，临床表现多样，其特征为皮肤屏障功能异常。高频超声检查（HF-USG）是一种在多种皮肤疾病中具有潜在应用价值的仪器。以往关于AD患者HF-USG的研究报告称，看似无皮损的皮肤也存在屏障缺陷。我们旨在使用HF-USG评估AD患者的皮损和非皮损皮肤，重点关注皮肤屏障功能和炎症。我们纳入了一组AD患者和一个对照组。对两组均进行了HF-USG分析。记录所有受试者（包括AD患者的活动性皮损及非皮损皮肤）的表皮下低回声带（SLEB）厚度和皮肤回声。对于AD患者，使用特应性皮炎评分（SCORing Atopic Dermatitis）来衡量临床严重程度，并与皮肤病生活质量指数（DLQI）相关联。AD患者皮损皮肤的低回声带平均厚度更宽。在AD患者的非皮损皮肤中也发现了SLEB，但较薄。对照组的皮肤回声高于AD患者。我们的结果表明，皮肤超声检查能够评估AD皮肤的特定改变。一些AD患者非皮损皮肤中的低回声带可能表明存在亚临床湿疹性病变。
