Nikkhah Bodagh Mehrnaz, Maleki Iradj, Hekmatdoost Azita
Student Research Committee Faculty of Nutrition and Food Technology Shahid Beheshti University of Medical Sciences Tehran Iran.
Gut and Liver Research Center Mazandaran University of Medical Sciences Sari Iran.
Food Sci Nutr. 2018 Nov 5;7(1):96-108. doi: 10.1002/fsn3.807. eCollection 2019 Jan.
Ginger, the rhizome of Zingiber officinale, which is used as a spice globally has a long history of medicinal use that stimulates investigators to assess its potential roles as an adjuvant therapy or alternative medicine in a range of diseases. Anti-inflammatory, antioxidant, antitumor, and antiulcer effects of ginger have been proven in many scientific studies, and some of the ancient applications of ginger as a home remedy has been confirmed in human. In this review, we summarized the current evidence on the effects of ginger consumption on gastrointestinal disorders based on clinical trials. Our data indicate that divided lower daily dosage of 1500 mg ginger is beneficial for nausea relief. Because of limited number of studies on some other gastrointestinal disorders, the results may not be as much powered as to find significant results. Therefore, more extensive and well-controlled human studies of ginger or its standard extracts are required to demonstrate its efficacy as a gastroprotective agent. Dose-finding studies should be undertaken to accurately determine the effective dose and preparation of ginger in further clinical trials protocol.
姜，即姜科植物姜的根茎，作为一种全球范围内使用的香料，其药用历史悠久，这促使研究人员评估其在一系列疾病中作为辅助治疗或替代药物的潜在作用。许多科学研究已证实姜具有抗炎、抗氧化、抗肿瘤和抗溃疡作用，并且姜作为家庭疗法的一些古老应用已在人体中得到证实。在本综述中，我们基于临床试验总结了当前关于食用姜对胃肠道疾病影响的证据。我们的数据表明，每日分剂量服用1500毫克姜有助于缓解恶心。由于关于其他一些胃肠道疾病的研究数量有限，结果可能没有足够的说服力来得出显著结果。因此，需要对姜或其标准提取物进行更广泛且严格对照的人体研究，以证明其作为胃保护剂的功效。应进行剂量探索研究，以在进一步的临床试验方案中准确确定姜的有效剂量和制剂。
