Dot Audrey, Bettega Georges, Lartizien Rodolphe, Berger Michel, Henry Maxime, Perriollat Mathieu, Coll Jean-Luc, Planat-Chretien Anne
INSERM UGA U1209, Institute For Advanced Biosciences, F- 38700, Grenoble, France.
Centre Hospitalier Annecy Genevois, F- 74374, Pringy, France.
Biomed Opt Express. 2021 Feb 5;12(3):1279-1294. doi: 10.1364/BOE.401108. eCollection 2021 Mar 1.
We report a method for deriving the absolute value of absorption coefficients at depth in bilayered media. The method was simplified from that of time-resolved diffuse optical tomography (TR-DOT) into one dimension to validate and set up the main parameters with the help of simulations, and to test it in an easy preclinical model. The method was applied to buried flaps as used in reconstructive surgery, and absolute chromophore concentrations in the flap and in the upper (skin and fat) layer were derived. The encouraging results obtained lay a foundation for developing more complex multidimensional models.
我们报告了一种用于推导双层介质中深度处吸收系数绝对值的方法。该方法是从时间分辨漫射光学层析成像（TR-DOT）方法简化而来，简化为一维形式，以便在模拟的帮助下验证和设置主要参数，并在一个简单的临床前模型中进行测试。该方法应用于重建手术中使用的埋藏皮瓣，并推导了皮瓣以及上层（皮肤和脂肪）层中发色团的绝对浓度。所获得的令人鼓舞的结果为开发更复杂的多维模型奠定了基础。
