Graduate Group in Integrative Pathobiology, University of California, Davis, United States; Center for Comparative Medicine, University of California, Davis, United States.
Graduate Group in Integrative Pathobiology, University of California, Davis, United States; Center for Comparative Medicine, University of California, Davis, United States; Dept. Pathology, Microbiology & Immunology, School of Veterinary Medicine, University of California, Davis, United States.
Curr Opin Immunol. 2019 Apr;57:23-31. doi: 10.1016/j.coi.2018.12.001. Epub 2019 Jan 24.
B-1 cells represent an innate-like early-developing B cell population, whose existence as an independent lymphocyte subset has been questioned in the past. Recent molecular and lineage tracing studies have not only confirmed their unique origins and differentiation paths, they have also provided a rationale for their distinctive functionalities compared to conventional B cells. This review summarizes our current understanding of B-1 cell development, and the activation events that regulate B-1 cell responses to self and foreign antigens. We discuss the unresolved question to what extent BCR engagement, that is, antigen-specificity versus innate signaling contributes to B-1 cell's participation in tissue homeostasis and immune defense as providers of 'natural' and antigen-induced antibody responses, and as cytokine-producing immune regulators.
B-1 细胞代表一种先天样的早期发育 B 细胞群体，其作为独立的淋巴细胞亚群的存在过去曾受到质疑。最近的分子和谱系追踪研究不仅证实了它们独特的起源和分化途径，还为它们与传统 B 细胞相比的独特功能提供了依据。这篇综述总结了我们目前对 B-1 细胞发育的理解，以及调节 B-1 细胞对自身和外来抗原反应的激活事件。我们讨论了一个尚未解决的问题，即 BCR 的结合在多大程度上促进了 B-1 细胞参与组织稳态和免疫防御，作为“天然”和抗原诱导的抗体反应的提供者，以及作为细胞因子产生的免疫调节剂。
