乳腺癌局部治疗的范式转变：从乳房切除术到保乳手术。
Paradigm shift in the local treatment of breast cancer: mastectomy to breast conservation surgery.
作者信息
Murugappan Kowsi, Saboo Apoorva, Kuo Lu, Ung Owen
机构信息
Royal Brisbane Breast Surgery Unit, Department of General Surgery, RBWH, Brisbane, Australia.
University of Queensland, Brisbane, Australia.
出版信息
Gland Surg. 2018 Dec;7(6):506-519. doi: 10.21037/gs.2018.09.01.
Abstract
There have been fundamental changes in the approach to breast cancer management over the last century but the primary objective of achieving oncological safety remains unchanged. This evolution is highlighted with a summary of the key evidences in support of the oncological safety of breast conserving surgery (BCS) in early breast cancer (EBC) management. We will also discuss the increasingly pivotal role that neoadjuvant chemotherapy (NACT) may play, in the local treatment of EBC and locally advanced breast cancer (LABC) and the long-term surgical and oncological outcomes.
摘要
在过去的一个世纪里，乳腺癌的治疗方法发生了根本性的变化，但实现肿瘤学安全性的首要目标始终未变。早期乳腺癌（EBC）治疗中支持保乳手术（BCS）肿瘤学安全性的关键证据总结突出了这一演变过程。我们还将讨论新辅助化疗（NACT）在EBC和局部晚期乳腺癌（LABC）的局部治疗中可能发挥的日益关键的作用，以及长期的手术和肿瘤学结果。
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