School of Ophthalmology and Optometry, Eye Hospital, School of Biomedical Engineering, Wenzhou Medical University, Wenzhou, Zhejiang Province 325035, P. R. China.
Chem Commun (Camb). 2019 Feb 12;55(14):2058-2061. doi: 10.1039/c8cc09986c.
It is of great interest to prepare osteogenic and antibacterial coatings for successful implants. Current coating techniques suffer from being time-consuming, substrate material or shape dependence, expensive equipment, environmental pollution, low stability, processes that are difficult to control, etc. Herein, inspired by mussels, we report a one-step and versatile method to fabricate a dual functional coating. The coating is finished in minutes independently of materials or dimensions of substrates. Thus, our coatings exhibit strong antibacterial ability against both Gram-positive bacteria S. aureus, and Gram-negative bacteria E. coli, support the proliferation of dental pulp stem cells (DPSCs), and are powerful for inducing osteogenic differentiation. The universality, facility, rapidness, and mildness of our coating process, which is also environmentally-friendly and cost-effective, points towards potential applications in bone or dental implants.
制备具有成骨和抗菌性能的涂层对于成功的植入物非常重要。目前的涂层技术存在耗时、对基底材料或形状的依赖性、昂贵的设备、环境污染、低稳定性、难以控制的工艺等问题。受贻贝启发，我们报告了一种一步法和通用的方法来制备双功能涂层。该涂层在几分钟内完成，独立于基底材料或尺寸。因此，我们的涂层表现出对革兰氏阳性菌金黄色葡萄球菌和革兰氏阴性菌大肠杆菌的强大抗菌能力，支持牙髓干细胞（DPSCs）的增殖，并能强力诱导成骨分化。我们的涂层工艺具有通用性、简便性、快速性和温和性，对环境友好且具有成本效益，有望在骨或牙科植入物中得到应用。
