Živković Zarić Radica S, Pejčić Ana V, Janković Slobodan M, Kostić Marina J, Milosavljević Miloš N, Milosavljević Marko J, Opančina Valentina D
a Faculty of Medical Sciences, University of Kragujevac , Kragujevac , Serbia.
J Chemother. 2019 May;31(3):109-119. doi: 10.1080/1120009X.2018.1542551. Epub 2019 Jan 28.
Objective of this systematic review was to establish whether and what invasive infections in humans were caused by Kocuria kristinae, and to evaluate outcomes of administered antibiotic treatment. MEDLINE, EBSCO, SCOPUS, SCINDEKS and GOOGLE SCHOLAR were systematically searched for primary case reports or case series describing invasive infections with K. kristinae. K. kristinae is a pathogen microorganism that could cause invasive infections of various tissues in patients of any age. Majority of the patients had K. kristinae isolated from blood. It was also found in peritoneal fluid, pus, sputum, synovial fluid, bile, fluid from abdominal abscess, throat swab, urine catheter tip and mid-stream urine. Antibiotic treatment was almost universally effective, with only one death reported. Susceptibility was highest to vancomycin, linezolid, rifampicin, teicoplanin, tigecycline, cefotaxime, ampicillin/sulbactam, minocycline and meropenem. Initial treatment of Kocuria kristinae infections should involve parenteral vancomycin in combination with some other antibiotic to which it is susceptible.
本系统评价的目的是确定人类侵袭性感染是否由克氏库克菌引起以及由其导致的是何种感染，并评估抗生素治疗的效果。我们系统检索了MEDLINE、EBSCO、SCOPUS、SCINDEKS和谷歌学术，以查找描述克氏库克菌侵袭性感染的原始病例报告或病例系列。克氏库克菌是一种致病微生物，可导致任何年龄患者的各种组织发生侵袭性感染。大多数患者的血液中分离出了克氏库克菌。在腹腔积液、脓液、痰液、滑液、胆汁、腹腔脓肿引流液、咽拭子、导尿管头端及中段尿中也发现了该菌。抗生素治疗几乎普遍有效，仅报告了1例死亡病例。对万古霉素、利奈唑胺、利福平、替考拉宁、替加环素、头孢噻肟、氨苄西林/舒巴坦、米诺环素和美罗培南的敏感性最高。克氏库克菌感染的初始治疗应采用静脉注射万古霉素联合其他敏感抗生素。
