J Am Dent Assoc. 2019 Feb;150(2):140-146. doi: 10.1016/j.adaj.2018.10.016.
As silver diamine fluoride (SDF) gains popularity for caries arrest, the authors aimed to investigate the content of fluoride and silver in 38% SDF produced for the US market and its short-term stability.
Five samples of 38% SDF were evaluated when the bottle was first opened, and at 7 and 28 days. Fluoride concentrations were determined with a fluoride ion-selective electrode, and silver concentrations were determined with a simultaneous inductively coupled plasma mass spectrometer. pH was measured with a pH probe. Weight and volume of individual drops were measured.
At day 0, 40% of individual measured values were above the expected fluoride concentration, and at day 28, 93% were above the expected fluoride concentration (P = .005). At day 0, 19% of individual measured values were below the lowest expected silver concentration, and at day 28, 93% were below (P < .001). Acidity (pH 10) was consistent over the 3 periods. Mean (standard deviation) weight of a drop was 40 (4.0) milligrams, and mean (standard deviation) volume was 32.55 (1.89) microliters, 30% more than the reported value of 25 μL.
Over 28 days, the product pH is stable, whereas the fluoride content tends to increase and the silver content tends to decrease. Drops were larger than expected when dispensed from the bottle.
Drops are larger than expected, so each delivers higher than expected quantities of silver and fluoride. Clinicians should exercise caution when using this product on young children, replace the cap immediately, and use as soon as dispensed.
随着银胺氟（SDF）在龋齿抑制方面的应用越来越广泛，作者旨在研究美国市场生产的 38%SDF 的氟化物和银含量及其短期稳定性。
对 38%SDF 的 5 个样本进行评估，评估时分别为刚开瓶时、第 7 天和第 28 天。使用氟离子选择电极测定氟化物浓度，同时采用电感耦合等离子体质谱法测定银浓度。用 pH 探头测量 pH 值，测量每个液滴的重量和体积。
在第 0 天，40%的个体测量值高于预期的氟化物浓度，而在第 28 天，93%的个体测量值高于预期的氟化物浓度（P =.005）。在第 0 天，19%的个体测量值低于预期的最低银浓度，而在第 28 天，93%的个体测量值低于预期的银浓度（P <.001）。在这三个时期，酸度（pH 值为 10）均保持稳定。每个液滴的平均（标准偏差）重量为 40（4.0）毫克，平均（标准偏差）体积为 32.55（1.89）微升，比报告的 25 μL 多出 30%。
在 28 天内，产品的 pH 值稳定，而氟化物含量呈上升趋势，银含量呈下降趋势。从瓶中分配出的液滴比预期的要大。
液滴比预期的大，因此每次分配的银和氟化物的量都高于预期。临床医生在给幼儿使用这种产品时应谨慎，应立即盖上瓶盖，并在分配后尽快使用。
