First Department of Pediatrics, National and Kapodistrian University of Athens, Choremeio Research Laboratory , Athens , Greece.
Leuk Lymphoma. 2019 Sep;60(9):2158-2169. doi: 10.1080/10428194.2019.1569230. Epub 2019 Jan 30.
Acute lymphoblastic leukemia (ALL) is the most common pediatric malignancy. Dysregulation of adipokine pathways is implicated in the carcinogenesis and ALL. The aim of this study is to present the most recent data available regarding the role of leptin, adiponectin and ghrelin in the pathogenesis and prognosis of ALL. The PubMed database was searched using 'Leptin', 'Adiponectin', 'Ghrelin', 'Cancer', 'Children' and 'Acute Lymphoblastic Leukemia' as keywords. The majority of the studies indicated that leptin levels are increased and adiponectin levels are decreased in ALL children at diagnosis, as well as in ALL survivors. Ghrelin levels were found to be lower at diagnosis and progressively increased during treatment. Further research is warranted, as the heterogeneity of the current studies, various treatment protocols and differences in sample sizes make it difficult to deduce solid conclusions regarding the role of adipokines in ALL.
急性淋巴细胞白血病（ALL）是最常见的儿科恶性肿瘤。脂肪因子通路的失调与癌症和 ALL 的发生有关。本研究旨在介绍目前关于瘦素、脂联素和胃饥饿素在 ALL 发病机制和预后中的作用的最新数据。使用“Leptin”、“Adiponectin”、“Ghrelin”、“Cancer”、“Children”和“Acute Lymphoblastic Leukemia”作为关键词在 PubMed 数据库中进行了搜索。大多数研究表明，ALL 患儿在诊断时以及 ALL 幸存者的瘦素水平升高，脂联素水平降低。在诊断时发现 ghrelin 水平较低，并且在治疗过程中逐渐升高。由于当前研究的异质性、不同的治疗方案以及样本量的差异，很难得出关于脂肪因子在 ALL 中的作用的明确结论，因此需要进一步研究。
