Oral Health Prev Dent. 2022 Jul 22;20:321-330. doi: 10.3290/j.ohpd.b3240829.
To present updated information on odontogenic keratocyst (OKC) classification, etiology, genetic and molecular alterations, epidemiology, clinical presentation, radiographic characteristics, histological and immune histochemical features, differential diagnosis, treatment, and controversies, as well as a literature review of case frequencies in different countries.
Studies were selected using the key words 'odontogenic keratocyst,' 'odontogenic cysts,' 'odontogenic keratocyst and clinical study'. Full-text papers were reviewed on the basis of the inclusion and exclusion criteria. The literature search aimed to find articles that would show the frequency of OKC, dentigerous cyst, radicular cyst, and other cysts.
OKC presents local aggression and high recurrence; therefore, a better understanding of its clinical characteristics and the genetic and molecular factors involved in this peculiar and controversial lesion is required. It is always essential to discuss treatment alternatives. Although OKC is an entity with a high recurrence, aggressive treatment is not advisable in all cases because factors such as commitment to anatomical structures and possible complications should be considered. However, periodic radiographic controls are advised.
To reduce the high number of present cases worldwide, it is important to improve knowledge on this pathology so that accurate diagnoses can be achieved and appropriate treatment can be provided. OKC presents local aggression and high recurrence; therefore, a better understanding is needed of the clinical characteristics and genetic and molecular factors involved in OKC. Furthermore, it is always essential to discuss treatment alternatives.
介绍牙源性角化囊肿（OKC）分类、病因、遗传和分子改变、流行病学、临床表现、影像学特征、组织学和免疫组织化学特征、鉴别诊断、治疗和争议的最新信息，并对不同国家的病例频率进行文献复习。
使用关键词“牙源性角化囊肿”、“牙源性囊肿”、“牙源性角化囊肿和临床研究”来选择研究。根据纳入和排除标准对全文进行了回顾。文献检索旨在寻找显示 OKC、含牙囊肿、根侧囊肿和其他囊肿频率的文章。
OKC 具有局部侵袭性和高复发率；因此，需要更好地了解其临床特征以及涉及这种特殊和有争议病变的遗传和分子因素。讨论治疗选择总是很重要的。虽然 OKC 是一种复发率高的实体，但并非所有情况下都建议采用激进的治疗方法，因为应考虑到对解剖结构的承诺和可能的并发症等因素。然而，建议进行定期影像学检查。
为了减少全球目前病例数量，提高对这种病理的认识非常重要，以便能够做出准确的诊断并提供适当的治疗。OKC 具有局部侵袭性和高复发率；因此，需要更好地了解其临床特征以及涉及 OKC 的遗传和分子因素。此外，讨论治疗选择总是很重要的。
