微生物群营养免疫及其与溃疡性结肠炎的相关性。
Microbiota-nourishing Immunity and Its Relevance for Ulcerative Colitis.
机构信息
Vanderbilt Institute for Infection, Immunology, and Inflammation and Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Department of Medical Microbiology and Immunology, School of Medicine, University of California at Davis, Davis, California, USA.
出版信息
Inflamm Bowel Dis. 2019 Apr 11;25(5):811-815. doi: 10.1093/ibd/izz004.
Abstract
An imbalance in our microbiota may contribute to many human diseases, but the mechanistic underpinnings of dysbiosis remain poorly understood. We argue that dysbiosis is secondary to a defect in microbiota-nourishing immunity, a part of our immune system that balances the microbiota to attain colonization resistance against environmental exposure to microorganisms. We discuss this new hypothesis and its implications for ulcerative colitis, an inflammatory bowel disease of the large intestine.
摘要
肠道微生物失衡可能导致许多人类疾病，但共生失调的机制仍知之甚少。我们认为，共生失调是由肠道微生物滋养免疫缺陷引起的，这是我们免疫系统的一部分，它可以平衡肠道微生物群，以获得对微生物环境暴露的定植抗性。我们讨论了这个新假设及其对溃疡性结肠炎（一种大肠炎症性肠病）的影响。
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