Wall M E, Wani M C, Manikumar G, Hughes T J, Taylor H, McGivney R, Warner J
Research Triangle Institute, Research Triangle Park, North Carolina 22709.
J Nat Prod. 1988 Nov-Dec;51(6):1148-52. doi: 10.1021/np50060a016.
Several coumarins were isolated from crude plant extracts by means of an antimutagenic assay procedure. These coumarins included psoralen from Psoralea corylifolia and imperatorin and osthol from Selinum monniere. Studies of structure-activity relationships of these and several other available coumarins were carried out with four mutagens. All of the coumarins were nontoxic and in particular showed high activity in the inhibition of the mutagenicity of benzo[a]pyrene.
通过抗诱变测定程序从植物粗提取物中分离出了几种香豆素。这些香豆素包括补骨脂中的补骨脂素以及水芹中的欧前胡素和蛇床子素。利用四种诱变剂对这些香豆素以及其他几种可用香豆素进行了构效关系研究。所有香豆素均无毒，尤其在抑制苯并[a]芘的诱变性方面表现出高活性。
