经颅磁刺激探测视皮层中的短潜伏期皮质抑制：一项可靠性研究。
Probing short-latency cortical inhibition in the visual cortex with transcranial magnetic stimulation: A reliability study.
机构信息
School of Kinesiology, University of Michigan, 401 Washtenaw Ave, 41809, Ann Arbor, MI, USA; Department of Psychology, University of Michigan, 530 Church Street, 48109, Ann Arbor, MI, USA.
Department of Psychology, University of Michigan, 530 Church Street, 48109, Ann Arbor, MI, USA.
出版信息
Brain Stimul. 2019 May-Jun;12(3):702-704. doi: 10.1016/j.brs.2019.01.013. Epub 2019 Jan 20.
BACKGROUND
Transcranial magnetic stimulation (TMS) is a non-invasive method to stimulate localized brain regions. Despite widespread use in motor cortex, TMS is seldom performed in sensory areas due to variable, qualitative metrics.
OBJECTIVE
Assess the reliability and validity of tracing phosphenes, and to investigate the stimulation parameters necessary to elicit decreased visual cortex excitability with paired-pulse TMS at short inter-stimulus intervals.
METHODS
Across two sessions, single and paired-pulse recruitment curves were derived by having participants outline elicited phosphenes and calculating resulting average phosphene sizes.
RESULTS
Phosphene size scaled with stimulus intensity, similar to motor cortex. Paired-pulse recruitment curves demonstrated inhibition at lower conditioning stimulus intensities than observed in motor cortex. Reliability was high across sessions.
CONCLUSIONS
TMS-induced phosphenes are a valid and reliable tool for measuring cortical excitability and inhibition in early visual areas. Our results also provide appropriate stimulation parameters for measuring short-latency intracortical inhibition in visual cortex.
背景
经颅磁刺激（TMS）是一种刺激局部脑区的非侵入性方法。尽管在运动皮层中广泛应用，但由于可变的、定性的指标，TMS 在感觉区很少进行。
目的
评估追踪光幻视的可靠性和有效性，并研究在短刺激间隔时使用双脉冲 TMS 诱发视觉皮层兴奋性降低所需的刺激参数。
方法
在两个会话中，通过让参与者描绘诱发的光幻视并计算出的平均光幻视大小，得出单脉冲和双脉冲募集曲线。
结果
光幻视大小与刺激强度呈比例关系，类似于运动皮层。双脉冲募集曲线显示，在比运动皮层观察到的更低的条件刺激强度下存在抑制。在各次试验中，可靠性均较高。
结论
TMS 诱导的光幻视是一种有效且可靠的工具，可用于测量早期视觉区域的皮质兴奋性和抑制性。我们的结果还为测量视觉皮层中的短潜伏期皮质内抑制提供了适当的刺激参数。
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