桔青霉全基因组测序揭示了霉菌毒素桔霉素的生物合成基因簇。
Whole-Genome Sequencing of the Fungus Penicillium citrinum Reveals the Biosynthesis Gene Cluster for the Mycotoxin Citrinin.
作者信息
Schmidt-Heydt Markus, Stoll Dominic, Geisen Rolf
机构信息
Department of Safety and Quality of Fruit and Vegetables, Max Rubner-Institut, Federal Research Institute of Nutrition and Food, Karlsruhe, Germany.
出版信息
Microbiol Resour Announc. 2019 Jan 24;8(4). doi: 10.1128/MRA.01419-18. eCollection 2019 Jan.
Abstract
Penicillium citrinum is a food-contaminating ascomycete that consistently produces large amounts of the mycotoxin citrinin. Citrinin exhibits, besides its toxicity, antibiotic effects and thus potentially forces antibiotic resistance. Within the genome sequence, we identified the biosynthesis gene cluster for citrinin, which appears to be highly conserved within the genus .
摘要
桔青霉是一种污染食品的子囊菌，能持续产生大量的桔霉素霉菌毒素。桔霉素除了具有毒性外，还具有抗生素作用，因此可能会导致抗生素耐药性。在基因组序列中，我们鉴定出了桔霉素的生物合成基因簇，该基因簇在该属中似乎高度保守。
相似文献
1
Whole-Genome Sequencing of the Fungus Penicillium citrinum Reveals the Biosynthesis Gene Cluster for the Mycotoxin Citrinin.桔青霉全基因组测序揭示了霉菌毒素桔霉素的生物合成基因簇。
Microbiol Resour Announc. 2019 Jan 24;8(4). doi: 10.1128/MRA.01419-18. eCollection 2019 Jan.
2
Comparative Transcriptome Analysis of Penicillium citrinum Cultured with Different Carbon Sources Identifies Genes Involved in Citrinin Biosynthesis.不同碳源培养的桔青霉的比较转录组分析确定了与桔霉素生物合成相关的基因。
Toxins (Basel). 2017 Feb 21;9(2):69. doi: 10.3390/toxins9020069.
3
Expression of citrinin biosynthesis gene in Liupao tea and effect of Penicillium citrinum on tea quality.黄曲霉素生物合成基因在六堡茶中的表达及桔青霉对茶叶品质的影响。
Fungal Genet Biol. 2022 Nov;163:103742. doi: 10.1016/j.fgb.2022.103742. Epub 2022 Sep 13.
4
Citrinin dimers from the halotolerant fungus Penicillium citrinum B-57.来自耐盐真菌桔青霉B-57的桔霉素二聚体。
J Nat Prod. 2008 Apr;71(4):543-6. doi: 10.1021/np0704708. Epub 2008 Feb 19.
5
Comparative metabolomics reveals defence-related modification of citrinin by Penicillium citrinum within a synthetic Penicillium-Pseudomonas community.比较代谢组学揭示了在合成青霉-假单胞菌群落中，青霉属（Penicillium citrinum）对桔青霉素（citrinin）的防御相关修饰作用。
Environ Microbiol. 2019 Jan;21(1):496-510. doi: 10.1111/1462-2920.14482. Epub 2018 Dec 19.
6
Production of lipase free of citrinin by Penicillium citrinum.青霉属产无桔青霉素脂肪酶。
Mycopathologia. 1996 Feb;133(2):119-21. doi: 10.1007/BF00439123.
7
Citrinin, a mycotoxin from Penicillium citrinum, plays a role in inducing motility of Paenibacillus polymyxa.桔霉素是一种来自桔青霉的霉菌毒素，在诱导多粘芽孢杆菌的运动性方面发挥作用。
FEMS Microbiol Ecol. 2008 Aug;65(2):229-37. doi: 10.1111/j.1574-6941.2008.00492.x. Epub 2008 May 1.
8
Antimicrobial activity of the mycotoxin citrinin obtained from the fungus penicillium citrinum.从真菌桔青霉中获得的霉菌毒素桔霉素的抗菌活性。
Anc Sci Life. 2002 Jan;21(3):191-7.
9
[Effect on microelements on biosynthes of secondary metabolites in the fungus Penicillium citrinum Thom VKM F-1079].[微量元素对桔青霉VKM F-1079次生代谢产物生物合成的影响]
Mikrobiologiia. 2000 Sep-Oct;69(5):642-6.
10
Effect of aqueous extracts of Mentha arvensis (mint) and Piper betle (betel) on growth and citrinin production from toxigenic Penicillium citrinum.薄荷（Mentha arvensis）和蒌叶（Piper betle）水提取物对产毒桔青霉生长及桔霉素产生的影响。
J Food Sci Technol. 2015 Jun;52(6):3466-74. doi: 10.1007/s13197-014-1390-y. Epub 2014 May 17.
引用本文的文献
1
Incorporating omics-based tools into endophytic fungal research.将基于组学的工具应用于内生真菌研究。
Biotechnol Notes. 2023 Dec 31;5:1-7. doi: 10.1016/j.biotno.2023.12.006. eCollection 2024.
2
Morphological and phylogenetic analyses reveal two new species isolated from the ancient Great Wall loess in Beijing, China.形态学和系统发育分析揭示了从中国北京古代长城黄土中分离出的两个新物种。
Front Microbiol. 2024 Mar 15;15:1329299. doi: 10.3389/fmicb.2024.1329299. eCollection 2024.
3
An oxidoreductase gene CtnD involved in citrinin biosynthesis in Monascus purpureus verified by CRISPR/Cas9 gene editing and overexpression.通过CRISPR/Cas9基因编辑和过表达验证的、参与红曲霉菌中桔霉素生物合成的氧化还原酶基因CtnD。
Mycotoxin Res. 2023 Aug;39(3):247-259. doi: 10.1007/s12550-023-00491-5. Epub 2023 Jun 3.
4
Current State and Future Directions of Genetics and Genomics of Endophytic Fungi for Bioprospecting Efforts.用于生物勘探的内生真菌遗传学和基因组学的现状与未来方向
Front Bioeng Biotechnol. 2021 Mar 15;9:649906. doi: 10.3389/fbioe.2021.649906. eCollection 2021.
5
The Good, the Bad, and the Ugly: Mycotoxin Production During Postharvest Decay and Their Influence on Tritrophic Host-Pathogen-Microbe Interactions.善、恶与丑：收获后腐烂过程中霉菌毒素的产生及其对三营养级宿主-病原体-微生物相互作用的影响。
Front Microbiol. 2021 Feb 12;12:611881. doi: 10.3389/fmicb.2021.611881. eCollection 2021.
6
A Compost Treatment Acts as a Suppressive Agent in Pathosystem by Modifying the Rhizosphere Microbiota.堆肥处理通过改变根际微生物群在病害系统中起到抑制作用。
Front Plant Sci. 2020 Jun 24;11:885. doi: 10.3389/fpls.2020.00885. eCollection 2020.
7
New Insight Into Pathogenicity and Secondary Metabolism of the Plant Pathogen Through Deletion of the Epigenetic Reader SntB.通过缺失表观遗传阅读器SntB对植物病原体致病性和次生代谢的新见解
Front Microbiol. 2020 Apr 9;11:610. doi: 10.3389/fmicb.2020.00610. eCollection 2020.
本文引用的文献
1
antiSMASH 3.0-a comprehensive resource for the genome mining of biosynthetic gene clusters.antiSMASH 3.0——用于生物合成基因簇基因组挖掘的综合资源。
Nucleic Acids Res. 2015 Jul 1;43(W1):W237-43. doi: 10.1093/nar/gkv437. Epub 2015 May 6.
2
Toxicity of the mycotoxin citrinin and its metabolite dihydrocitrinone and of mixtures of citrinin and ochratoxin A in vitro.霉菌毒素桔霉素及其代谢物二氢桔霉素酮以及桔霉素与赭曲霉毒素A混合物的体外毒性
Arch Toxicol. 2014 May;88(5):1097-107. doi: 10.1007/s00204-014-1216-8. Epub 2014 Feb 28.
3
Isolation and characterization of the citrinin biosynthetic gene cluster from Monascus aurantiacus.从桔青霉中分离和鉴定桔霉素生物合成基因簇。
Biotechnol Lett. 2012 Jan;34(1):131-6. doi: 10.1007/s10529-011-0745-y. Epub 2011 Sep 29.
4
antiSMASH: rapid identification, annotation and analysis of secondary metabolite biosynthesis gene clusters in bacterial and fungal genome sequences.antiSMASH：快速识别、注释和分析细菌和真菌基因组序列中次生代谢产物生物合成基因簇。
Nucleic Acids Res. 2011 Jul;39(Web Server issue):W339-46. doi: 10.1093/nar/gkr466. Epub 2011 Jun 14.
5
Secondary metabolites characteristic of Penicillium citrinum, Penicillium steckii and related species.桔青霉、施氏青霉及相关物种的次生代谢产物特征。
Phytochemistry. 2000 Jun;54(3):301-9. doi: 10.1016/s0031-9422(00)00106-0.
6
ML-236A, ML-236B, and ML-236C, new inhibitors of cholesterogenesis produced by Penicillium citrinium.ML-236A、ML-236B和ML-236C，由桔青霉产生的新型胆固醇生物合成抑制剂。
J Antibiot (Tokyo). 1976 Dec;29(12):1346-8. doi: 10.7164/antibiotics.29.1346.
Zotero 插件