Opt Lett. 2019 Feb 1;44(3):654-657. doi: 10.1364/OL.44.000654.
Fiber-optic endomicroscopy is a minimally invasive tool to probe disease progression with subcellular resolution. In this Letter, we demonstrate a low-cost and compact fluorescence microendoscope capable of line-scanning confocal imaging by synchronizing a digital light projector with a CMOS camera. We present the digital aperture design to enable real-time confocal imaging, and we implement parallel illumination to improve the optical sectioning performance. Furthermore, we show that the confocal microendoscope can enhance visualization of disease-associated features when imaging highly scattering esophageal specimens.
光纤内窥显微镜是一种用于探测疾病进展的微创工具，具有亚细胞分辨率。在本信中，我们展示了一种低成本、紧凑的荧光微内窥镜，通过数字投影仪与 CMOS 相机同步实现线扫描共聚焦成像。我们设计了数字孔径以实现实时共聚焦成像，并采用平行照明来提高光学切片性能。此外，我们还展示了当对高度散射的食管标本成像时，共聚焦微内窥镜可增强与疾病相关特征的可视化效果。
