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一种用于组织工程和水修复的简便双功能杂化材料的制备方法。

A Facile Approach to Fabricate Dual Purpose Hybrid Materials for Tissue Engineering and Water Remediation.

机构信息

Advanced Materials Laboratory, Central Leather Research Institute (Council of Scientific and Industrial Research), Chennai, India.

出版信息

Sci Rep. 2019 Jan 31;9(1):1040. doi: 10.1038/s41598-018-37758-2.

DOI:10.1038/s41598-018-37758-2
PMID:30705331
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6355841/
Abstract

Creating hybrid materials with multifunctionality and robust mechanical stability from natural resources is a challenging proposition in materials science. Here, we report the scalable synthesis of hybrid collagen scaffolds using collagen extracted from leather industry wastes and sago starch derived from agro-industry. The hybrid scaffolds were incorporated with TiO nanoparticles and cross-linked with oxidized sago starch. The biocompatibility, thermal stability and antimicrobial property of hybrid scaffold enabled its application in burn wound healing demonstrated through albino rat models. The highly porous hybrid scaffolds are shown to be super-compressible, which is typically forbidden in materials of biological origin. We demonstrate that the hybrid scaffolds concurrently display both adsorption and absorption behavior in the removal of oil and dye molecules, respectively from contaminated water. This study paves the way for the development of novel multifunctional and shape recoverable hybrid materials specifically from renewable resources.

摘要

从自然资源中创造具有多功能性和稳健机械稳定性的混合材料是材料科学中的一个具有挑战性的命题。在这里,我们报告了使用从制革工业废物中提取的胶原蛋白和从农业工业中提取的西米淀粉合成混合胶原支架的可扩展方法。将混合支架与 TiO2 纳米粒子结合,并与氧化的西米淀粉交联。通过白化大鼠模型证明了混合支架的生物相容性、热稳定性和抗菌性能使其可应用于烧伤创面愈合。高多孔混合支架具有超可压缩性,这在生物来源材料中通常是禁止的。我们证明,混合支架在去除受污染水中的油和染料分子时,分别表现出吸附和吸收行为。本研究为开发新型多功能和形状可恢复的混合材料铺平了道路,这些材料特别来自可再生资源。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/18ee/6355841/9cf0561b7c8f/41598_2018_37758_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/18ee/6355841/54d46b3f2a35/41598_2018_37758_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/18ee/6355841/b96d8f71bbf1/41598_2018_37758_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/18ee/6355841/6882c6b52f1c/41598_2018_37758_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/18ee/6355841/468a5c433fe3/41598_2018_37758_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/18ee/6355841/7e5368187045/41598_2018_37758_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/18ee/6355841/9cf0561b7c8f/41598_2018_37758_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/18ee/6355841/54d46b3f2a35/41598_2018_37758_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/18ee/6355841/b96d8f71bbf1/41598_2018_37758_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/18ee/6355841/6882c6b52f1c/41598_2018_37758_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/18ee/6355841/468a5c433fe3/41598_2018_37758_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/18ee/6355841/7e5368187045/41598_2018_37758_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/18ee/6355841/9cf0561b7c8f/41598_2018_37758_Fig6_HTML.jpg

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