Zhao Haiping, Han Ziping, Li Guangwen, Zhang Sijia, Luo Yumin
1Cerebrovascular Diseases Research Institute, Xuanwu Hospital of Capital Medical University, Beijing, China.
2Center of Stroke, Beijing Institute for Brain Disorders, Beijing, China.
Aging Dis. 2017 Dec 1;8(6):721-739. doi: 10.14336/AD.2017.0724. eCollection 2017 Dec.
Owing to a dramatic increase in average life expectancy, most countries in the world are rapidly entering an aging society. Therefore, extending health span with pharmacological agents targeting aging-related pathological changes, are now in the spotlight of gerosciences. (Burk.) F. H. Chen, a species of the genus Panax, has been called the "Miracle Root for the Preservation of Life," and has long been used as a Chinese herb with magical medicinal value. has been extensively employed in China to treat microcirculatory disturbances, inflammation, trauma, internal and external bleeding due to injury, and as a tonic. In recent years, with the deepening of the research pharmacologically, many new functions have been discovered. This review will introduce its pharmacological function on lifespan extension, anti-vascular aging, anti-brain aging, and anti-cancer properties, aiming to lay the ground for fully elucidating the potential mechanisms of anti-aging effect to promote its clinical application.
由于平均预期寿命急剧增加，世界上大多数国家正在迅速步入老龄化社会。因此，利用针对衰老相关病理变化的药物来延长健康寿命，目前已成为老年科学领域的研究热点。人参属的一种植物（Burk.）F.H. Chen，被誉为“生命保存的神奇之根”，长期以来一直作为具有神奇药用价值的中草药使用。在中国，它已被广泛用于治疗微循环障碍、炎症、创伤、内外伤出血，并作为滋补品。近年来，随着药理学研究的深入，人们发现了许多新功能。本综述将介绍其在延长寿命、抗血管衰老、抗脑衰老和抗癌方面的药理作用，旨在为全面阐明其抗衰老作用的潜在机制以促进其临床应用奠定基础。
