Liao Yuxiao, Peng Zhao, Chen Liangkai, Zhang Yan, Cheng Qian, Nüssler Andreas K, Bao Wei, Liu Liegang, Yang Wei
1Department of Nutrition and Food Hygiene, Hubei Key Laboratory of Food Nutrition and Safety, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
2MOE Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Aging Dis. 2019 Feb 1;10(1):157-173. doi: 10.14336/AD.2018.0325. eCollection 2019 Feb.
Skeletal muscle aging is characterized by decline in skeletal muscle mass and function along with growing age, which consequently leads to age-related sarcopenia, if without any preventive timely treatment. Moreover, age-related sarcopenia in elder people would contribute to falls and fractures, disability, poor quality of life, increased use of hospital services and even mortality. Whey protein (WP) and/or resistance training (RT) has shown promise in preventing and treating age-related sarcopenia. It seems that sex hormones could be potential contributors for gender differences in skeletal muscle and age-related sarcopenia. In addition, skeletal muscle and the development of sarcopenia are influenced by gut microbiota, which in turn is affected by WP or RT. Gut microbiota may be a key factor for WP and/or RT against age-related sarcopenia. Therefore, focusing on sex hormones and gut microbiota may do great help for preventing, treating and better understanding age-related sarcopenia.
骨骼肌衰老的特征是随着年龄增长，骨骼肌质量和功能下降，如果不及时进行预防性治疗，会导致与年龄相关的肌肉减少症。此外，老年人中与年龄相关的肌肉减少症会导致跌倒、骨折、残疾、生活质量下降、医院服务使用增加甚至死亡。乳清蛋白（WP）和/或抗阻训练（RT）在预防和治疗与年龄相关的肌肉减少症方面已显示出前景。性激素似乎可能是骨骼肌和与年龄相关的肌肉减少症性别差异的潜在因素。此外，骨骼肌和肌肉减少症的发展受肠道微生物群的影响，而肠道微生物群又受WP或RT的影响。肠道微生物群可能是WP和/或RT对抗与年龄相关的肌肉减少症的关键因素。因此，关注性激素和肠道微生物群可能对预防、治疗以及更好地理解与年龄相关的肌肉减少症有很大帮助。
