İstanbul University, Istanbul Faculty of Medicine, Pediatric Endocrinology Unit, İstanbul, Turkey.
Best Pract Res Clin Endocrinol Metab. 2019 Jun;33(3):101260. doi: 10.1016/j.beem.2019.01.001. Epub 2019 Jan 22.
The children with intrauterine growth restriction (IUGR) especially if they make a catch-up growth in early life have a higher risk for long term problems including short stature and also developing metabolic syndrome, Type 2 diabetes, insulin resistance and cardiovascular diseases. The studies also support that these children may have abnormalities in pubertal timing, adrenarche and reproductive function. The aim of this review was to summarize the published reports mainly on puberty and reproductive functions in children born IUGR at older ages in association with metabolic problems that they encounter. Possible mechanisms explaining these outcomes are discussed. Lastly strategies that may be taken for the prevention of IUGR related morbidities at later life are shortly presented.
宫内生长受限（IUGR）的儿童，尤其是在生命早期有追赶性生长的儿童，长期风险更高，包括身材矮小以及代谢综合征、2 型糖尿病、胰岛素抵抗和心血管疾病的发生。研究还表明，这些儿童可能在青春期、肾上腺功能初现和生殖功能方面存在异常。本综述的目的是总结主要关于宫内生长受限儿童在成年期与代谢问题相关的青春期和生殖功能的已发表报告。讨论了可能解释这些结果的机制。最后，简要介绍了可能用于预防生命后期与 IUGR 相关的发病率的策略。
