Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA; Harvard Medical School, Boston, MA, USA.
Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA; Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Alzheimers Dement. 2019 Apr;15(4):525-533. doi: 10.1016/j.jalz.2018.11.004. Epub 2019 Jan 29.
We examined the relation between self-reported hearing loss, hearing aid use, and risk of subjective cognitive function (SCF) decline.
We conducted an 8-year (2008-2016) longitudinal study of 10,107 men aged ≥62 years who reported their hearing status in 2006 and had no subjective cognitive concerns in 2008. Change in SCF scores was assessed by a 6-item questionnaire, and subjective decline was defined as new report of at least one SCF concern during follow-up.
Hearing loss was associated with higher risk of SCF decline. Compared with no hearing loss, the multivariable-adjusted relative risk (95% CI) of incident SCF decline was 1.30 (1.18, 1.42), 1.42 (1.26, 1.61), and 1.54 (1.22, 1.96) among men with mild, moderate, and severe hearing loss (no hearing aids), respectively (P-trend < .001). Among men with severe hearing loss who used hearing aids, the multivariable-adjusted relative risk (95% CI) was 1.37 (1.18, 1.60).
Hearing loss was associated with substantially higher risk of subsequent subjective cognitive decline in men.
我们研究了自我报告的听力损失、助听器使用与主观认知功能（SCF）下降风险之间的关系。
我们进行了一项为期 8 年（2008-2016 年）的纵向研究，纳入了 10107 名年龄≥62 岁的男性，他们在 2006 年报告了自己的听力状况，且在 2008 年没有主观认知问题。SCF 评分的变化通过一个包含 6 个问题的问卷进行评估，主观下降定义为在随访期间新报告至少一项 SCF 问题。
听力损失与 SCF 下降风险增加相关。与无听力损失相比，轻度、中度和重度听力损失（无助听器）男性发生 SCF 下降的多变量校正相对风险（95%CI）分别为 1.30（1.18，1.42）、1.42（1.26，1.61）和 1.54（1.22，1.96）（趋势 P<.001）。在使用助听器的重度听力损失男性中，多变量校正相对风险（95%CI）为 1.37（1.18，1.60）。
听力损失与男性随后发生主观认知下降的风险显著增加相关。
