男性听力损失与主观认知功能下降的纵向研究。
Longitudinal study of hearing loss and subjective cognitive function decline in men.
机构信息
Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA; Harvard Medical School, Boston, MA, USA.
Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA; Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
出版信息
Alzheimers Dement. 2019 Apr;15(4):525-533. doi: 10.1016/j.jalz.2018.11.004. Epub 2019 Jan 29.
INTRODUCTION
We examined the relation between self-reported hearing loss, hearing aid use, and risk of subjective cognitive function (SCF) decline.
METHODS
We conducted an 8-year (2008-2016) longitudinal study of 10,107 men aged ≥62 years who reported their hearing status in 2006 and had no subjective cognitive concerns in 2008. Change in SCF scores was assessed by a 6-item questionnaire, and subjective decline was defined as new report of at least one SCF concern during follow-up.
RESULTS
Hearing loss was associated with higher risk of SCF decline. Compared with no hearing loss, the multivariable-adjusted relative risk (95% CI) of incident SCF decline was 1.30 (1.18, 1.42), 1.42 (1.26, 1.61), and 1.54 (1.22, 1.96) among men with mild, moderate, and severe hearing loss (no hearing aids), respectively (P-trend < .001). Among men with severe hearing loss who used hearing aids, the multivariable-adjusted relative risk (95% CI) was 1.37 (1.18, 1.60).
DISCUSSION
Hearing loss was associated with substantially higher risk of subsequent subjective cognitive decline in men.
简介
我们研究了自我报告的听力损失、助听器使用与主观认知功能（SCF）下降风险之间的关系。
方法
我们进行了一项为期 8 年（2008-2016 年）的纵向研究，纳入了 10107 名年龄≥62 岁的男性，他们在 2006 年报告了自己的听力状况，且在 2008 年没有主观认知问题。SCF 评分的变化通过一个包含 6 个问题的问卷进行评估，主观下降定义为在随访期间新报告至少一项 SCF 问题。
结果
听力损失与 SCF 下降风险增加相关。与无听力损失相比，轻度、中度和重度听力损失（无助听器）男性发生 SCF 下降的多变量校正相对风险（95%CI）分别为 1.30（1.18，1.42）、1.42（1.26，1.61）和 1.54（1.22，1.96）（趋势 P<.001）。在使用助听器的重度听力损失男性中，多变量校正相对风险（95%CI）为 1.37（1.18，1.60）。
讨论
听力损失与男性随后发生主观认知下降的风险显著增加相关。
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