Department of Immunology and Pathology, Monash University, Melbourne, VIC, Australia.
Immunol Cell Biol. 2019 Mar;97(3):289-298. doi: 10.1111/imcb.12241.
Immune cells are rapidly recruited to a site of injury or infection. Although the importance of phagocytic immune cells in clearing bacteria has long been appreciated, the advent of technologies allowing more in-depth analysis of cellular function, such as intravital microscopy and the use of genetically modified animal models, has allowed much deeper insight into the complex roles of these cells play during tissue repair. Many immune cells contribute to the repair process; however, this review will concentrate on the involvement of the phagocytes, namely macrophages and neutrophils, with a particular focus on our more recent understanding of how interactions between these two cell types impact on the final outcome of tissue repair.
免疫细胞会迅速被募集到损伤或感染部位。尽管吞噬免疫细胞在清除细菌方面的重要性早已被人们所认识，但随着能够更深入地分析细胞功能的技术的出现，如活体显微镜和基因修饰动物模型的应用，人们对这些细胞在组织修复过程中所扮演的复杂角色有了更深入的了解。许多免疫细胞都有助于修复过程；然而，本篇综述将集中讨论吞噬细胞（即巨噬细胞和中性粒细胞）的参与，特别关注我们最近对这两种细胞类型之间相互作用如何影响组织修复最终结果的理解。
