非麸质小麦敏感：一种具有全身表现的免疫介导疾病。
Nonceliac Wheat Sensitivity: An Immune-Mediated Condition with Systemic Manifestations.
机构信息
Department of Medical and Surgical Sciences, St. Orsola-Malpighi Hospital, University of Bologna, Via Zamboni, 33, Bologna BO 40126, Italy.
Department of Medical Sciences, Nuovo Arcispedale St. Anna in Cona, University of Ferrara, Via Savonarola, 9, Ferrara FE 44121, Italy.
出版信息
Gastroenterol Clin North Am. 2019 Mar;48(1):165-182. doi: 10.1016/j.gtc.2018.09.012. Epub 2018 Dec 13.
Abstract
Non-celiac wheat sensitivity (NCWS) is characterized by gastrointestinal and extra-intestinal symptoms following the ingestion of gluten-containing cereals in subjects without celiac disease or wheat allergy. The identity of the molecular triggers in these cereals responsible for the symptoms of NCWS remains to be delineated. Recent research has identified a biological basis for the condition, with the observation of systemic immune activation in response to microbial translocation that appears to be linked to intestinal barrier defects. Ongoing research efforts are aimed at further characterizing the etiology, mechanism, and biomarkers of the condition.
摘要
非麸质小麦敏感（NCWS）的特征是在无乳糜泻或小麦过敏的患者摄入含麸质谷物后出现胃肠道和肠外症状。这些谷物中导致 NCWS 症状的分子触发因素的身份仍有待确定。最近的研究为这种疾病确定了生物学基础，观察到对微生物易位的全身性免疫激活，这似乎与肠道屏障缺陷有关。目前的研究工作旨在进一步描述该疾病的病因、机制和生物标志物。
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