Aksorn Nithikoon, Chanvorachote Pithi
Department of Clinical Pathology, Faculty of Medicine Vajira Hospital, Navamindradhiraj University, Bangkok, Thailand.
Department of Pharmacology and Physiology, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok, Thailand
Anticancer Res. 2019 Feb;39(2):541-548. doi: 10.21873/anticanres.13146.
Integrins are cell-matrix adhesion molecules providing both mechanical engagement of cell to extracellular matrix, and generation of cellular signals that are implicated in cancer malignancies. The concept that integrins play important roles in cell survival, proliferation, motility, differentiation, and ensuring appropriate cell localization, leads to the hypothesis that inhibition of certain integrins would benefit cancer therapy. In lung cancer, integrins αv, α5, β1, β3, and β5 have been shown to augment survival and metastatic potential of cancer cells. This review presents data suggesting integrins as molecular targets for anti-cancer approaches, and the mechanisms through which integrins confer resistance of lung cancer to chemotherapeutics and metastasis. The better understanding of these key molecules may benefit the discovery of anti-cancer drugs and strategies.
整合素是细胞与细胞外基质的粘附分子，既能使细胞与细胞外基质进行机械性结合，又能产生与癌症恶性肿瘤相关的细胞信号。整合素在细胞存活、增殖、迁移、分化以及确保细胞正确定位中发挥重要作用，这一概念引发了如下假说：抑制某些整合素将有利于癌症治疗。在肺癌中，整合素αv、α5、β1、β3和β5已被证明可增强癌细胞的存活和转移潜能。本综述展示了相关数据，表明整合素可作为抗癌方法的分子靶点，以及整合素赋予肺癌对化疗药物耐药性和转移能力的机制。对这些关键分子的深入了解可能有助于抗癌药物和策略的发现。
