Department of Medical Microbiology, Radboud University Medical Center, PO Box 9101, 6500 HB, Nijmegen, The Netherlands; Radboud Center for Infectious Diseases, Radboud University Medical Center, PO Box 9101, 6500 HB, Nijmegen, The Netherlands.
University Medical Center Utrecht, PO Box 85500, Utrecht, The Netherlands.
Trends Immunol. 2019 Mar;40(3):186-196. doi: 10.1016/j.it.2019.01.002. Epub 2019 Jan 31.
Recently, a population of non-recirculating, tissue-resident memory CD8 T cells has been identified; cells that seems to act as key sentinels for invading microorganisms with enhanced effector functions. In malaria, the liver represents the first site for parasite development before a definite infection is established in circulating red blood cells. Here, we discuss the evidence obtained from animal models on several diseases and hypothesize that liver-resident memory CD8 T cells (hepatic T) play a critical role in providing protective liver-stage immunity against Plasmodium malaria parasites. Although observations in human malaria trials are limited to peripheral blood, we propose recommendations for the translation of some of these findings to human malaria research.
最近，人们发现了一群非循环、组织驻留的记忆 CD8 T 细胞；这些细胞似乎作为入侵微生物的关键哨兵，具有增强的效应功能。在疟疾中，肝脏是寄生虫在循环红细胞中建立明确感染之前发育的第一个部位。在这里，我们讨论了从几种疾病的动物模型中获得的证据，并假设肝驻留记忆 CD8 T 细胞（肝 T 细胞）在提供针对疟原虫疟疾寄生虫的保护性肝期免疫方面发挥着关键作用。尽管人类疟疾试验中的观察结果仅限于外周血，但我们提出了将其中一些发现转化为人类疟疾研究的建议。
