Chakraborty Priyadarshi, Gazit Ehud
Department of Molecular Microbiology and Biotechnology, George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv 6997801, Israel.
Department of Materials Science and Engineering, Iby and Aladar Fleischman Faculty of Engineering, Tel Aviv University, Tel Aviv 6997801, Israel.
ChemNanoMat. 2018 Aug;4(8):730-740. doi: 10.1002/cnma.201800147.
Amino acids are the simplest biological building blocks capable of forming discreet nanostructures by supramolecular self-assembly. The understanding of the process of organization of amino acid nanostructures is of fundamental importance for the study of metabolic diseases as well as for materials science applications. Although peptide self-assembled structures have been the topic of many review articles, much less attention has been devoted to the ability of amino acid building blocks, both natural and synthetic, to form ordered assemblies with defined architectures and notable physical properties, by the process of self-association. Herein, we try to shed light on amino acid based nanostructures, their fabrication and implications. We discuss self-assembled nanostructures, including hydrogels with nanoscale order, obtained from both modified and unmodified single amino acids. We also envision some future prospects in this emerging field.
氨基酸是能够通过超分子自组装形成离散纳米结构的最简单生物构建单元。理解氨基酸纳米结构的组织过程对于研究代谢疾病以及材料科学应用至关重要。尽管肽自组装结构一直是许多综述文章的主题，但天然和合成氨基酸构建单元通过自缔合过程形成具有明确结构和显著物理性质的有序组装体的能力却很少受到关注。在此，我们试图阐明基于氨基酸的纳米结构、它们的制备方法及其意义。我们讨论了自组装纳米结构，包括从修饰和未修饰的单个氨基酸获得的具有纳米级有序性的水凝胶。我们还展望了这个新兴领域的一些未来前景。
