DermAssociates, Silver Spring, Maryland; Georgetown University, Washington, DC; Johns Hopkins University, Baltimore, Maryland.
Johns Hopkins University, Baltimore, Maryland; Montefiore Medical Center, Bronx, New York.
J Am Acad Dermatol. 2018 Aug;79(2):345-352. doi: 10.1016/j.jaad.2018.02.040. Epub 2018 Mar 2.
In addition to being recognized as a chronic inflammatory disease that manifests in the skin, psoriasis is increasingly understood to be a systemic disease that causes immune dysregulation throughout the body. The systemic nature of psoriasis is evidenced by the higher burden of comorbidities and shorter life expectancies of patients with psoriasis, particularly those with early-onset and severe disease. Notably, psoriasis is associated with an increased risk for cardiovascular disease, which is the most common cause of morbidity and mortality in patients with psoriasis. In this review, we examine the association between psoriasis and cardiovascular disease and specifically focus on the role of interleukin 17-mediated inflammation as a potential mechanistic link between psoriasis and cardiovascular disease. Moreover, we describe potential treatment approaches to reduce the burden of cardiovascular disease in patients with psoriasis and discuss the clinical importance of the association of these 2 diseases with respect to patient management and education.
除了被认为是一种表现为皮肤炎症的慢性炎症性疾病外，银屑病越来越被认为是一种全身性疾病，会导致全身免疫失调。银屑病的全身性特征表现为患有银屑病的患者合并症负担更高，预期寿命更短，尤其是那些发病早且病情严重的患者。值得注意的是，银屑病与心血管疾病风险增加有关，心血管疾病是银屑病患者发病率和死亡率的最常见原因。在这篇综述中，我们研究了银屑病与心血管疾病之间的关联，并特别关注白细胞介素 17 介导的炎症在银屑病和心血管疾病之间可能的机制联系中的作用。此外，我们描述了潜在的治疗方法，以降低银屑病患者心血管疾病的负担，并讨论了这两种疾病之间关联的临床重要性，这与患者的管理和教育有关。
