D'Angelo Gabriella, Granese Roberta, Marseglia Lucia, Impellizzeri Pietro, Alibrandi Angela, Palmara Antonella, La Rosa Maria Angela, Manti Sara, Salpietro Carmelo, Spina Edoardo, Reiter Russel J, Falsaperla Raffaele, Corsello Giovanni, Gitto Eloisa
Department of Clinical and Experimental Medicine, University of Messina, Messina, Italy.
Neonatal Intensive Care Unit, Gaetano Barresi Department of Human Pathology in Adult and Developmental Age, University of Messina, Messina, Italy.
Pediatr Int. 2019 Mar;61(3):264-270. doi: 10.1111/ped.13795.
Parturition induces considerable oxidative stress and many inflammatory mediators, such as high mobility group box 1 (HMGB1), are involved from the beginning of the pregnancy to birth. The aim of the present study was to evaluate serum cord blood concentration of diacron-reactive oxygen metabolites (d-ROM), biological antioxidant potential (BAP), and HMGB1 to investigate the perinatal oxidative status of neonates and correlation with mode of delivery, as well as the influence of labor.
The subjects consisted of 214 neonates delivered at University Hospital "G. Martino", Messina, in a 6 months period. Venous blood samples were collected from the umbilical cord after cord separation.
Umbilical cord venous blood HMGB1 was significantly higher in the spontaneous vaginal delivery (SVD) group than in the elective or emergency cesarean section (CS) group (P = 0.018). Regarding labor, there was no significant difference in HMGB1 concentration in umbilical vein blood between the spontaneous and induced labor groups (P = 0.250). Furthermore, d-ROM was significantly different between the SVD group and the elective or emergency CS group (P = 0.044). BAP concentration, however, was not significantly different, not even with regard to mode of labor.
Oxidation is higher in newborns delivered by SVD than in those delivered by CS, and HMGB1 may be involved in the mechanisms of birth, and responsible for decidual modifications that lead to birth.
分娩会引发相当程度的氧化应激，从妊娠开始到分娩，许多炎症介质都参与其中，如高迁移率族蛋白B1（HMGB1）。本研究的目的是评估脐血中双时相反应性氧代谢产物（d-ROM）、生物抗氧化潜力（BAP）和HMGB1的血清浓度，以研究新生儿围产期氧化状态及其与分娩方式的相关性，以及产程的影响。
研究对象为在墨西拿“G. Martino”大学医院6个月内分娩的214例新生儿。脐带分离后从脐静脉采集静脉血样本。
自然阴道分娩（SVD）组脐静脉血HMGB1显著高于择期或急诊剖宫产（CS）组（P = 0.018）。关于产程，自然分娩组和引产组脐静脉血中HMGB1浓度无显著差异（P = 0.250）。此外，SVD组与择期或急诊CS组之间d-ROM有显著差异（P = 0.044）。然而，BAP浓度无显著差异，甚至在产程方面也无差异。
SVD分娩的新生儿氧化程度高于CS分娩的新生儿，HMGB1可能参与分娩机制，并导致导致分娩的蜕膜改变。
