Research Center for High Altitude Medicine, Qinghai University, Xining, 810001, Qinghai, China.
Key Laboratory for Application of High-Altitude Medicine in Qinghai Province, Xining, China.
Reprod Sci. 2021 Mar;28(3):659-664. doi: 10.1007/s43032-020-00443-9. Epub 2021 Jan 19.
Labor and vaginal delivery cause acute ischemic/hypoxic insult to the placenta. Previous studies demonstrate that placentas from high altitude non-natives showed blunted responses to ischemic/hypoxic insult caused by labor and vaginal birth, and there were some differences in the ATP/ADP production ratio. We hypothesized that adapted highlanders would not have a stress response to the acute hypoxia/ischemia of labor. Tibetan laboring (n = 10) and non-laboring (n = 5) and European descendants laboring (n = 10) and non-laboring (n = 5) high-altitude placentas were analyzed using genome-wide expression array analysis. There was no evidence for ischemic/hypoxic stress in high-altitude Tibetan laboring as compared with non-laboring placentas, while there were differences in gene expression between laboring and non-laboring placentas from high-altitude European descendants. Our results provide evidence for adaptation to acute hypoxic ischemic insult caused by labor and vaginal birth in placentas in a high-altitude native Tibetan population.
分娩和阴道分娩会导致胎盘发生急性缺血/缺氧损伤。先前的研究表明，来自高海拔非本地人的胎盘对分娩和阴道分娩引起的缺血/缺氧损伤的反应较为迟钝，并且三磷酸腺苷/二磷酸腺苷（ATP/ADP）产生比率存在一些差异。我们假设适应了高海拔环境的高原居民不会对分娩时的急性缺氧/缺血产生应激反应。本研究使用全基因组表达谱分析方法分析了 10 例分娩和 5 例非分娩的西藏高原产妇胎盘，以及 10 例分娩和 5 例非分娩的欧洲裔后裔高原产妇胎盘。与非分娩胎盘相比，高海拔西藏分娩胎盘并没有证据表明存在缺血/缺氧应激，而高海拔欧洲裔后裔分娩和非分娩胎盘之间的基因表达存在差异。本研究结果为高海拔本地藏族人群的胎盘适应由分娩和阴道分娩引起的急性低氧缺血损伤提供了证据。
