Zhongda Hospital, School of Medicine, Southeast University, Nanjing, People's Republic of China; Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, People's Republic of China.
The Second People's Hospital of Kunshan, Kunshan, People's Republic of China.
Life Sci. 2019 Mar 1;220:156-161. doi: 10.1016/j.lfs.2019.01.056. Epub 2019 Feb 1.
Magnetic nanoparticles (MNPs) are promising candidates for drug delivery and treatment of various disorders. Toxicity evaluation is a critical point in the development of nanoformulations and therefore, draws considerable attention. Formulations involving individual or combinatorial nanoparticle suspensions might be used for targeted delivery and treatment. This might be a evaluated further for safety related issues considering future medications based on MNPs. Nanoparticle distribution in the body is dependent on its surface characteristics. Size, dose and routes of nanoparticle entry have to be taken into consideration for future assays.
磁性纳米粒子（MNPs）是药物输送和治疗各种疾病的有前途的候选者。毒性评估是纳米制剂开发的关键点，因此引起了相当大的关注。涉及单个或组合纳米颗粒悬浮液的制剂可用于靶向输送和治疗。这可能会进一步评估与安全性相关的问题，考虑基于 MNPs 的未来药物。纳米粒子在体内的分布取决于其表面特性。未来的检测必须考虑纳米粒子进入的大小、剂量和途径。
