Liquid Chromatography Mass Spectrometry (LCMS) Platform, Monash University Malaysia, Jalan Lagoon Selatan, Bandar Sunway 47500, Selangor Darul Ehsan, Malaysia.
Jeffrey Cheah School of Medicine and Health Sciences, Monash University Malaysia, Jalan Lagoon Selatan, Bandar Sunway 47500, Selangor Darul Ehsan, Malaysia.
Toxins (Basel). 2019 Feb 1;11(2):75. doi: 10.3390/toxins11020075.
Cancer is a deadly disease and there is an urgent need for the development of effective and safe therapeutic agents to treat it. Snake venom is a complex mixture of bioactive proteins that represents an attractive source of novel and naturally-derived anticancer agents. Malaysia is one of the world's most biodiverse countries and is home to various venomous snake species, including cobras. , , and are three of the most common cobra species in Malaysia and are of medical importance. Over the past decades, snake venom has been identified as a potential source of therapeutic agents, including anti-cancer agents. This present review highlights the potential anticancer activity of the venom and purified venom protein of , and . In conclusion, this review highlights the important role of the venom from Malaysian cobras as an important resource that researchers can exploit to further investigate its potential in cancer treatment.
癌症是一种致命的疾病，因此迫切需要开发有效且安全的治疗药物来治疗它。蛇毒是一种复杂的生物活性蛋白质混合物，是新型天然抗癌药物的有吸引力的来源。马来西亚是世界上生物多样性最丰富的国家之一，拥有各种毒蛇物种，包括眼镜蛇。眼镜王蛇、金环蛇和银环蛇是马来西亚最常见的三种眼镜蛇，具有医学重要性。在过去的几十年中，蛇毒已被确定为治疗药物的潜在来源，包括抗癌药物。本综述重点介绍了蛇毒和纯化 venom protein 的潜在抗癌活性 ， 和 。总之，本综述强调了马来西亚眼镜蛇毒液的重要作用，作为研究人员可以利用的重要资源，以进一步研究其在癌症治疗中的潜力。
