通过核磁共振波谱法测量发现，血浆镁含量较低与女性患2型糖尿病的风险增加有关：一项荷兰前瞻性队列研究的结果
Lower Plasma Magnesium, Measured by Nuclear Magnetic Resonance Spectroscopy, is Associated with Increased Risk of Developing Type 2 Diabetes Mellitus in Women: Results from a Dutch Prospective Cohort Study.
作者信息
Schutten Joëlle C, Gomes-Neto António W, Navis Gerjan, Gansevoort Ron T, Dullaart Robin P F, Kootstra-Ros Jenny E, Danel Richard M, Goorman Frans, Gans Rijk O B, de Borst Martin H, Jeyarajah Elias J, Shalaurova Irina, Otvos James D, Connelly Margery A, Bakker Stephan J L
机构信息
Department of Internal Medicine, Division of Nephrology, University of Groningen, University Medical Center Groningen, Hanzeplein 1, 9700RB Groningen, The Netherlands.
Department of Endocrinology, University of Groningen, University Medical Center Groningen, Hanzeplein 1, 9700RB Groningen, The Netherlands.
出版信息
J Clin Med. 2019 Feb 1;8(2):169. doi: 10.3390/jcm8020169.
BACKGROUND
Low circulating magnesium (Mg) is associated with an increased risk of developing type 2 diabetes mellitus (T2DM). We aimed to study the performance of a nuclear magnetic resonance (NMR)-based assay that quantifies ionized Mg in EDTA plasma samples and prospectively investigate the association of Mg with the risk of T2DM.
METHODS
The analytic performance of an NMR-based assay for measuring plasma Mg was evaluated. We studied 5747 subjects free of T2DM at baseline in the Prevention of Renal and Vascular End-stage Disease (PREVEND) study.
RESULTS
Passing⁻Bablok regression analysis, comparing NMR-measured ionized Mg with total Mg measured by the Roche colorimetric assay, produced a correlation of 0.90, with a slope of 1.08 (95% CI: 1.00⁻1.13) and an intercept of 0.02 (95% CI: -0.02⁻0.08). During a median follow-up period of 11.2 (IQR: 7.7⁻12.0) years, 289 (5.0%) participants developed T2DM. The association of NMR-measured ionized Mg with T2DM risk was modified by sex (P = 0.007). In women, we found an inverse association between Mg and the risk of developing T2DM, independent of adjustment for potential confounders (HR: 1.80; 95% CI: 1.20⁻2.70). In men, we found no association between Mg and the risk of developing T2DM (HR: 0.90; 95%: 0.67⁻1.21).
CONCLUSION
Lower NMR-measured plasma ionized Mg was independently associated with a higher risk of developing T2DM in women, but not in men.
背景
循环镁（Mg）水平低与2型糖尿病（T2DM）发生风险增加相关。我们旨在研究一种基于核磁共振（NMR）的检测方法的性能，该方法可定量测定乙二胺四乙酸（EDTA）血浆样本中的游离镁，并前瞻性地研究镁与T2DM风险的关联。
方法
评估了一种基于NMR的血浆镁检测方法的分析性能。我们在预防肾和血管终末期疾病（PREVEND）研究中对5747名基线时无T2DM的受试者进行了研究。
结果
通过Passing⁻Bablok回归分析，将NMR测定的游离镁与罗氏比色法测定的总镁进行比较，相关性为0.90，斜率为1.08（95%CI：1.00⁻1.13），截距为0.02（95%CI：-0.02⁻0.08）。在中位随访期11.2（四分位间距：7.7⁻12.0）年期间，289名（5.0%）参与者发生了T2DM。NMR测定的游离镁与T2DM风险的关联因性别而异（P = 0.007）。在女性中，我们发现镁与发生T2DM的风险呈负相关，独立于对潜在混杂因素的调整（HR：1.80；95%CI：1.20⁻2.70）。在男性中，我们未发现镁与发生T2DM的风险之间存在关联（HR：0.90；95%：0.67⁻1.21）。
结论
较低的NMR测定血浆游离镁与女性发生T2DM的较高风险独立相关，但与男性无关。
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