Chemistry Department, Amazonas Federal University, Av. Rodrigo Octavio, 6200, Manaus AM 69080-900, Brazil.
Department of Pharmacy, Federal University of Rio Grande do Norte, Natal RN 59012-570, Brazil.
Int J Mol Sci. 2019 Feb 2;20(3):642. doi: 10.3390/ijms20030642.
This review aims to provide a critical review of the biological performance of natural and synthetic substances complexed with cyclodextrins, highlighting: (i) inclusion complexes with cyclodextrins and their biological studies in vitro and in vivo; (ii) Evaluation and comparison of the bioactive efficacy of complexed and non-complexed substances; (iii) Chemical and biological performance tests of inclusion complexes, aimed at the development of new pharmaceutical products. Based on the evidence presented in the review, it is clear that cyclodextrins play a vital role in the development of inclusion complexes which promote improvements in the chemical and biological properties of the complexed active principles, as well as providing improved solubility and aqueous stability. Although the literature shows the importance of their ability to help produce innovative biotechnological substances, we still need more studies to develop and expand their therapeutic properties. It is, therefore, very important to gather together evidence of the effectiveness of inclusion complexes with cyclodextrins in order to facilitate a better understanding of research on this topic and encourage further studies.
本文旨在对与环糊精复合的天然和合成物质的生物学性能进行综述，重点介绍：（i）与环糊精的包合物及其在体外和体内的生物学研究；（ii）复合和未复合物质的生物活性功效的评估和比较；（iii）旨在开发新药物产品的包合物的化学和生物学性能测试。基于综述中呈现的证据，显然环糊精在包合物的开发中起着至关重要的作用，它促进了复合活性成分的化学和生物学性质的改善，同时提供了更好的溶解度和水稳定性。尽管文献表明它们帮助生产创新型生物技术物质的能力非常重要，但我们仍需要更多的研究来开发和扩展其治疗特性。因此，收集环糊精包合物有效性的证据非常重要，以促进对该主题的研究的更好理解，并鼓励进一步的研究。
