Department of Materials Engineering, Ilse Katz Institute for Nanoscale Science & Technology, Ben-Gurion University of the Negev, Beer Sheva 84105, Israel.
Int J Mol Sci. 2019 Feb 2;20(3):646. doi: 10.3390/ijms20030646.
Natural Killer (NK) cells are innate lymphocytes that contribute to immune protection by cytosis, cytokine secretion, and regulation of adaptive responses of T cells. NK cells distinguish between healthy and ill cells, and generate a cytotoxic response, being cumulatively regulated by environmental signals delivered through their diverse receptors. Recent advances in biomaterials and device engineering paved the way to numerous artificial microenvironments for cells, which produce synthetic signals identical or similar to those provided by the physiological environment. In this paper, we review recent advances in materials and devices for artificial signaling, which have been applied to regulate NK cells, and systematically study the role of these signals in NK cell function.
自然杀伤 (NK) 细胞是先天淋巴细胞，通过细胞凋亡、细胞因子分泌和调节 T 细胞适应性反应来促进免疫保护。NK 细胞能够区分健康细胞和病态细胞，并产生细胞毒性反应，其活性受到通过其各种受体传递的环境信号的累积调节。生物材料和器件工程的最新进展为细胞创造了许多人工微环境，这些微环境产生的合成信号与生理环境提供的信号相同或相似。本文综述了用于人工信号传递的材料和设备的最新进展，这些进展已应用于调节 NK 细胞，并系统地研究了这些信号在 NK 细胞功能中的作用。
