Bozkurt Hüseyin Sancar, Quigley Eamonn Mm, Kara Banu
Clinic of Gastroenterology, Medical Park Private Tarsus Hospital, Mersin, Turkey.
Division of Gastroenterology and Hepatology, Lynda K and David M Underwood Center for Digestive Disorders, Houston Methodist Hospital and Weill Cornell Medical College, Houston, TX, USA.
SAGE Open Med. 2019 Jan 22;7:2050312119825784. doi: 10.1177/2050312119825784. eCollection 2019.
Colorectal cancer is the third most common cancer and the third leading cause of cancer-related death. The pathogensesis of colorectal cancer involves a multi-step and multi-factorial process. Disruption of the gut microbiota has been associated with gastrointestinal diseases such as colorectal cancer. The genus is considered an important component of the commensal microbiota and plays important roles in several homeostatic functions: immune, neurohormonal, and metabolic. subsp. is a well-documented probiotic within the species Mycosporin-like amino acids are low molecular weight amino acids demonstrated to exert prebiotic effects and to modulate host immunity by regulating the proliferation and differentiation of intestinal epithelial cells, macrophages and lymphocytes, as well as cytokine production.Their modulation of the metabolism of the immune system and transcription factors could exert a beneficial effect on colorectal cancer. does not produce mycosporin-like amino acids. If one could create a -producing mycosporin-like amino acids via genetic open reading frame engineering it should exert more potent immuno-stimulatory properties and, thereby, become a potent strain-specific microbial based therapy in colorectal cancer prevention.
结直肠癌是第三大常见癌症，也是癌症相关死亡的第三大主要原因。结直肠癌的发病机制涉及一个多步骤、多因素的过程。肠道微生物群的破坏与诸如结直肠癌等胃肠道疾病有关。该属被认为是共生微生物群的重要组成部分，并在多种稳态功能中发挥重要作用：免疫、神经激素和代谢。亚种是该物种中有充分文献记载的益生菌。类菌孢素氨基酸是低分子量氨基酸，已证明其具有益生元作用，并通过调节肠道上皮细胞、巨噬细胞和淋巴细胞的增殖与分化以及细胞因子的产生来调节宿主免疫力。它们对免疫系统代谢和转录因子的调节可能对结直肠癌产生有益影响。不产生类菌孢素氨基酸。如果能够通过基因开放阅读框工程创造出一种能产生类菌孢素氨基酸的菌株，它应该会具有更强的免疫刺激特性，从而成为预防结直肠癌的一种有效的基于菌株的微生物疗法。
