Olsson G L, Hallén B
Acta Anaesthesiol Scand. 1982 Oct;26(5):417-20. doi: 10.1111/j.1399-6576.1982.tb01791.x.
Children admitted for emergency operations because of trauma run a high risk of chemical aspiration pneumonitis syndrome. Fifty-eight children admitted for closed reduction of fractures and suturing of wounds were studied in a double-blind manner in order to see if metoclopramide could be of value in decreasing the risk of aspiration during anaesthesia. Metoclopramide given before anaesthesia proved to enhance gastric evacuation and could thus be of value in these situations. In addition, the study showed that the time from last oral intake until start of anaesthesia is of less importance then the type of trauma in prolonging the gastric emptying time and thus increasing the risk of vomiting and aspiration of vomitus into the lungs during anaesthesia.
因创伤而接受急诊手术的儿童发生化学性误吸性肺炎综合征的风险很高。为了探究甲氧氯普胺是否有助于降低麻醉期间误吸的风险，对58名因骨折闭合复位和伤口缝合而入院的儿童进行了双盲研究。结果表明，麻醉前给予甲氧氯普胺可促进胃排空，因此在这些情况下可能具有一定价值。此外，研究还显示，从最后一次口服摄入到开始麻醉的时间，在延长胃排空时间从而增加麻醉期间呕吐和呕吐物误吸入肺的风险方面，不如创伤类型重要。
